Table 3

Effects of NIM on the development of tongue lesions in rats initiated by 4-NQO

Group no.TreatmentEffective no. of ratsaTongue lesionsSize distribution of SCCs (%) diameter (mm)
Incidence (%)Multiplicity (no./rat)
HPbDPPAPSCCHPDPPAPSCC<33–10<10
14-NQO alone117 (63.6)10 (90.9)2 (22.2)9 (81.8)1.09 ± 1.042.18 ± 1.400.22 ± 0.441.00 ± 0.773 (27.3)2 (18.1)6 (54.5)
24-NQO+ 150 ppm NIM129 (75.0)11 (91.7)5 (41.7)4 (33.3)c1.50 ± 1.171.83 ± 1.190.42 ± 0.510.33 ± 0.49c1 (25.0)2 (50.0)1 (25.0)
34-NQO+ 300 ppm NIM1311 (84.6)13 (100)3 (23.1)1 (7.7)d1.23 ± 0.832.00 ± 1.000.23 ± 0.440.08 ± 0.28e001 (100)
44-NQO+ 600 ppm NIM127 (58.3)10 (83.3)3 (25.0)5 (41.7)0.75 ± 0.751.08 ± 0.670.25 ± 0.450.50 ± 0.674 (66.7)02 (33.3)
  • a Based on histological examination.

  • b HP, hyperplasia; DP, dysplasia; PAP, squamous cell papilloma.

  • c Significantly different from Group 1 (P < 0.05).

  • d Significantly different from Group 1 (P < 0.0005).

  • e Significantly different from Group 1 (P < 0.01).