Table 1

COX-1 and -2 inhibition potencies in human recombinant whole cell and whole blood assays

CompoundHuman recombinant Chinese hampster ovary cell IC50m)a,b,cHuman whole blood IC50m)d
COX-1COX-2COX-1COX-2
Rofecoxib>20.000.02190.5
Sulindac>100>100
Sulindac sulfide0.0280.0041.0210.43
Sulindac sulfone>100>100
  • a IC50, concentration at which 50% inhibition of prostaglandin product occurs in each assay.

  • b Ref. 21 .

  • c Ref. 39 .

  • d Ref. 40 .