Table 2

Plasma concentrations of rofecoxib and sulindac and its metabolites in Apc|gD716 mice

GroupSample no.Inhibitor (μg/ml)Average inhibitor (μg/ml)SD
Vioxx, 0.0075%2-10.198
14.7 mg/kg/day2-20.217
2-30.222
2-40.169
2-50.229
2-60.3280.230.05
Vioxx, 0.0025%3-10.024
4.7 mg/kg/day3-20.059
3-30.073
3-40.043
3-50.0170.040.02
Sulindac, 0.015%4-12.485
32.6 mg/kg/day4-20.726
Sulindac4-30.266
4-42.476
4-52.0571.61.04
Sulindac, 0.015%4-13.00
Sulindac sulfide4-21.29
4-31.54
4-41.48
4-51.571.780.69
Sulindac, 0.015%4-115.66
Sulindac sulfone4-26.11
4-34.87
4-412.80
4-512.5610.44.67