Table 1

Biodistribution data for [18F]Galacto-RGD in melanoma-bearing nude mice and osteosarcoma-bearing mice

Values are given as % ID/g ± SD.
Time p.i. (min)Osteosarcoma (αvβ3 positive)Melanoma M21 (αvβ3 positive)Melanoma M21-L (negative control)
Blood
 102.58 ± 0.412.93 ± 0.534.70a
 600.27 ± 0.060.18 ± 0.060.26 ± 0.06
 1200.13 ± 0.030.05 ± 0.010.13 ± 0.07
Serum
 105.25 ± 0.335.65 ± 0.898.71
 600.50 ± 0.120.34 ± 0.110.49 ± 0.11
 1200.19 ± 0.040.09 ± 0.010.22 ± 0.10
Liver
 105.47 ± 0.115.64 ± 2.276.40
 602.94 ± 0.271.85 ± 0.392.07 ± 0.20
 1201.97 ± 0.271.25 ± 0.051.79 ± 0.58
Kidneys
 108.67 ± 0.528.48 ± 0.8410.82
 603.11 ± 0.601.86 ± 0.102.24 ± 0.21
 1202.21 ± 0.461.52 ± 0.101.86 ± 0.46
Muscle
 100.80 ± 0.131.13 ± 0.181.44
 600.32 ± 0.060.21 ± 0.020.21 ± 0.03
 1200.28 ± 0.020.15 ± 0.020.18 ± 0.03
Spleen
 102.54 ± 0.072.10 ± 0.452.39
 601.54 ± 0.220.69 ± 0.100.77 ± 0.02
 1201.20 ± 0.040.64 ± 0.090.73 ± 0.14
Heart
 101.94 ± 0.051.85 ± 0.242.02
 600.51 ± 0.070.28 ± 0.050.34 ± 0.02
 1200.63 ± 0.410.19 ± 0.040.29 ± 0.06
Tumor
 102.88 ± 0.323.90 ± 1.361.88
 601.33 ± 0.201.56 ± 0.150.42 ± 0.09
 1201.68 ± 0.491.49 ± 0.100.44 ± 0.24
Lung
 103.43 ± 0.243.64 ± 0.524.84
 601.10 ± 0.180.76 ± 0.090.83 ± 0.08
 1200.72 ± 0.150.53 ± 0.050.71 ± 0.24
Femur
 101.22 ± 0.041.51 ± 0.341.46
 600.54 ± 0.110.34 ± 0.050.44 ± 0.06
 1200.51 ± 0.020.33 ± 0.020.50 ± 0.10
Colon
 103.77 ± 0.161.74 ± 0.551.68
 602.27 ± 1.230.57 ± 0.040.70 ± 0.19
 1201.59 ± 0.463.53 ± 0.440.76 ± 0.27
Brain
 100.14 ± 0.010.19 ± 0.040.19
 600.06 ± 0.010.05 ± 0.010.05 ± 0.01
 1200.05 ± 0.010.04 ± 0.010.05 ± 0.01
  • a Data for this time point result from one mouse.