Table 1

Enhancement of therapeutic effects of adoptive immunotherapy by concomitant α4-1BB administration

Mean no. of pulmonary metastases (SE)
No. of cells transferredα4-1BB treatmentDay 3 tumorsDay 10 tumors
0NDa88 (18)
0+232 (36)80 (26)
5 × 106199 (38)ND
5 × 106+32 (15)b3 (2)
10 × 10649 (24)20 (12)
10 × 106+4.4 (2.1)b1.2 (1.6)b
20 × 1064.4 (4)1.2 (1.9)
20 × 106+00.8 (1.2)
  • a ND, not done.

  • b Significantly different from the group of mice receiving the same numbers of activated LN cells but not treated with 4-1BB mAb (P < 0.05).