Table 1

Pathology of prostate and metastasis of 12T-10 mice

Age (months)Tag no. of mouseHistology of the prostateMetastatic sites
Anterior lobeDorsal lobeLateral lobeVentral lobe
21015LGPIN, HGPINLGPIN, HGPINLGPIN, HGPINLGPIN, HGPINNone
1016LGPIN, HGPINLGPIN, HGPINHGPINLGPIN, HGPINNone
1017LGPIN, HGPINHGPINHGPINLGPIN, HGPINNone
1018LGPIN, HGPINLGPIN, HGPINLGPIN, HGPINLGPIN, HGPINNone
1023LGPIN, HGPINLGPIN, HGPINLGPIN, HGPINLGPIN, HGPINNone
31024LGPIN, HGPINLGPIN, HGPINLGPIN, HGPINLGPIN, HGPINNone
1025LGPIN, HGPINLGPIN, HGPINLGPIN, HGPINLGPIN, HGPINNone
1380LGPIN, HGPINLGPIN, HGPINHGPINHGPINNone
1381LGPIN, HGPINLGPIN, HGPINHGPINHGPINNone
1382LGPIN, HGPINLGPIN, HGPINHGPINLGPIN, HGPINNone
41026LGPIN, HGPINLGPIN, HGPINHGPINLGPIN, HGPINNone
1027LGPIN, HGPINLGPIN, HGPINHGPINLGPIN, HGPINNone
1028LGPIN, HGPINHGPINHGPINHGPINNone
1035HGPIN, MIaLGPIN, HGPINHGPINHGPINNone
1036LGPIN, HGPINLGPIN, HGPINHGPINHGPINNone
51042HGPINLGPIN, HGPINHGPIN, MIHGPINNone
1043HGPINHGPINHGPINHGPINNone
1048HGPINLGPIN, HGPINHGPINHGPINNone
1049HGPINHGPINHGPINHGPINNone
1050HGPINHGPINHGPINHGPIN, MINone
67211HGPINHGPINHGPINHGPINNone
7216HGPINHGPINHGPIN, MI, ICneHGPIN, MINone
7491HGPIN, MIHGPIN, MIHGPINHGPINRLN
7495HGPINHGPIN, MIHGPINHGPIN, MI, ICadBoneb
7591HGPINHGPIN, MIHGPINHGPINNone
77122HGPINHGPINHGPIN, MIHGPIN, MINone
7125HGPINHGPIN, MIHGPIN, MIHGPINSkin
7127HGPINHGPIN, MIHGPIN, MIHGPINRLN
7486HGPIN, MIHGPIN, MIHGPIN, MI, ICadHGPINNone
7489HGPIN, MIHGPIN, MIHGPIN, MI, ICneHGPIN, MINone
8455HGPIN, MI, ICneUCUCNARLN, liver, lung, skin
7126HGPIN, MI, ICadHGPIN, MIHGPINHGPIN, MINone
7410HGPIN, MIHGPIN, MIHGPIN, MIHGPIN, MINone
7411HGPINHGPIN, MI, ICHGPIN, MIHGPIN, MIRLN
7413HGPINHGPIN, MIHGPINHGPIN, MINone
9–103283HGPIN, MI, ICneHGPIN, MI, ICadHGPINNARLN, liver, lung, spleen, kidney
7221HGPINHGPIN, MIHGPIN, MIHGPIN, UCLiver
7222HGPINHGPIN, MIHGPIN, MIHGPIN, MILung
7408HGPIN, MI, ICadHGPIN, MI, ICHGPIN, MIHGPIN, MI, UCcRLN,d liver,d lung
7409HGPIN, MIHGPIN, MI, ICadHGPIN, MIHGPIN, MIBoneb
7424HGPINHGPIN, MIHGPIN, MIHGPINNone
7603HGPIN, MI, ICneHGPIN, MIHGPINHGPINRLN, liver, lung, adrenal, MLN
11–1266HGPIN, MI, ICadHGPIN, MI, ICHGPIN, MIHGPIN, MIRLN, liver, lung
67HGPIN, MIUCUCNARLN, liver
465HGPIN, MIHGPIN, MI, ICadHGPIN, MI, ICHGPINRLN, liver, lung, spleen, kidney
488HGPIN, MIHGPIN, MI, ICad,neHGPIN, MI, ICadHGPIN, MIRLN, liver, lung
489HGPIN, MI, ICad,neHGPIN, MI, UCHGPIN, MI, UCHGPIN, MI, UCRLN, liver, lung
848HGPIN, MI, ICadHGPINHGPIN, MIHGPIN, MILiver, lung
849HGPIN, MIHGPIN, MI, ICadHGPIN, MIHGPIN, MIRLN, liver, lung
970HGPIN, MIHGPIN, MI, ICadHGPIN, MI, ICadHGPIN, MIRLN, liver, lung, spleen, boneb
973HGPIN, ICadHGPIN, MIHGPIN, MIHGPINNone
2372HGPIN, MI, ICHGPIN, MI, ICad, UCHGPIN, MI, ICad, UCUCRLN, liver, lung
  • a MI, microinvasion; IC, invasive carcinoma without histological features of glandular or neuroendocrine differentiation; ICad, invasive carcinoma with glandular differentiation; ICne, invasive carcinoma with neuroendocrine differentiation; ICad,ne, invasive carcinoma with glandular and neuroendocrine differentiation; RLN, regional lymph nodes; MLN, submandibular lymph nodes; NA, not available.

  • b Bone metastases by Tag-positive immunostaining.

  • c The ventral lobe which had nodular neuroendocrine carcinoma was transplanted in an athymic male mouse to establish an allograft model and provided for mass spectrometry analysis.

  • d Regional lymph nodes and liver that had Tag-positive lesions were provided for mass spectrometry analysis.