RT-PCR results and serum tumor marker levels in nonmetastatic colorectal cancer patients
| Serum CEA levels were determined by an enzyme immunoassay test kit, using a value of 5 ng/ml as positive. CA19.9 was determined using the CA19.9 kit with the suggested value 37 units/ml as positive. Serum CA72-4 antigen levels were determined using the CA72-4 kit with the suggested value 6 units/ml as positive. | |||||||
|---|---|---|---|---|---|---|---|
| Patient | Site of primary | Stage | Site of metastasis | Serum levels | CEA RT-PCR | ||
| CEA (ng/ml) | CA19.9 (units/ml) | CA72-4 (units/ml) | |||||
| 1 | Colon | A | 2.9 (−) | 8.0 (−) | 1.7 (−) | − | |
| 2 | Rectum | A | 1.4 (−) | 39.9 (+) | 10.0 (+) | +++ | |
| 3 | Rectum | A | 0.8 (−) | 3.7 (−) | 0.1 (−) | − | |
| 4 | Colon | A | 0.6 (−) | 25.6 (−) | 1.9 (−) | ++ | |
| 5 | Colon | A | 0.6 (−) | 12.2 (−) | 2.1 (−) | − | |
| 6 | Colon | A | 0.5 (−) | 15.3 (−) | 1.4 (−) | − | |
| 7 | Rectum | B1 | 3.0 (−) | 6.2 (−) | 1.8 (−) | ++ | |
| 8 | Rectum | B1 | 2.8 (−) | 30.9 (−) | 0.7 (−) | ++ | |
| 9 | Rectum | B1 | 2.7 (−) | 4.8 (−) | 2.0 (−) | − | |
| 10 | Rectum | B1 | 2.1 (−) | 7.0 (−) | 1.9 (−) | − | |
| 11 | Sigma | B1 | 11.5 (+) | 8.3 (−) | 0.9 (−) | + | |
| 12 | Rectum | B1 | 0.9 (−) | 15.8 (−) | 2.2 (−) | − | |
| 13 | Colon/Rectum | B1a | 1.7 (−) | 8.7 (−) | 2.4 (−) | ++ | |
| 14 | Colon | B2 | 77.3 (+) | 40.0 (+) | 22.9 (+) | ++ | |
| 15 | Sigma | B2 | 3.1 (−) | 9.3 (−) | 4.5 (−) | +++ | |
| 16 | Rectum | B2 | 1.8 (−) | 7.4 (−) | 12.5 (+) | + | |
| 17 | Rectum | B2 | 1.7 (−) | 7.3 (−) | 2.1 (−) | + | |
| 18 | Rectum | B2 | 1.4 (−) | 4.0 (−) | 0.8 (−) | − | |
| 19 | Rectum | B2 | 1.1 (−) | 8.1 (−) | 1.8 (−) | + | |
| 20 | Colon | B2 | 0.4 (−) | 18.3 (−) | 3.4 (−) | − | |
| 21 | Colon | B2 | 0.2 (−) | 2.2 (−) | 3.0 (−) | − | |
| 22 | Rectum | C1 | 6.2 (+) | 12.7 (−) | 1.8 (−) | + | |
| 23 | Rectum | C1 | 1.0 (−) | 12.1 (−) | 2.3 (−) | + | |
| 24 | Colon | C1 | 0.5 (−) | 8.9 (−) | 2.0 (−) | + | |
| 25 | Sigma | C2 | 16.1 (+) | 0.1 (−) | 1.6 (−) | − | |
| 26 | Colon | C2 | 5.6 (+) | 0.4 (−) | 0.4 (−) | ++ | |
| 27 | Colon | C2 | 1.2 (−) | 87.1 (+) | 18.5 (+) | ++ | |
| 28 | Rectum | C2 | 0.8 (−) | 6.2 (−) | 2.3 (−) | + | |
| 29 | Rectum | C2 | 0.6 (−) | 11.8 (−) | 2.8 (−) | +++ | |
| 30 | Colon | D | Liver | 433.5 (+) | 1364.2 (+) | 18.9 (+) | + |
| 31 | Colon | D | Liver | 311.6 (+) | 6490.1 (+) | 31.3 (+) | +++ |
| 32 | Colon | D | Liver | 257.4 (+) | 44.7 (+) | 65.3 (+) | + |
| 33 | Sigma | D | Liver | 139.0 (+) | 963.0 (+) | 151.9 (+) | − |
| 34 | Colon | D | Multiple | 126.2 (+) | 53.4 (+) | 2.6 (−) | + |
| 35 | Cecum | D | Liver | 20.5 (+) | 75.8 (+) | 0.7 (−) | + |
| 36 | Rectum | D | Peritoneum | 20.0 (+) | 238.6 (+) | 15.5 (+) | + |
| 37 | Colon | D | Liver | 13.5 (+) | 84.6 (+) | 22.5 (+) | +++ |
| 38 | Rectum | D | Liver | 10.2 (+) | 2.0 (−) | 0.1 (−) | +++ |
| 39 | Colon | D | Peritoneum | 8.7 (+) | 1.7 (−) | 3.8 (−) | + |
| 40 | Rectum | D | Lung-Liver | 5.0 (+) | 43.4 (+) | 2.0 (−) | + |
| 41 | Rectum | D | Liver | 4.7 (−) | 25.7 (−) | 1.6 (−) | + |
| 42 | Colon | D | Liver | 4.2 (−) | 34.9 (−) | 0.1 (−) | + |
| 43 | Rectum | D | Liver | 2.1 (−) | 8.3 (−) | 2.8 (−) | − |
| 44 | Colon | D | Multiple | 1.5 (−) | 99.5 (+) | 22.7 (+) | − |
| 45 | Colon | D | Liver | 1.5 (−) | 148.3 (+) | 10.2 (+) | − |
| 46 | Sigma | D | Liver | 1.0 (−) | 0.4 (−) | 0.3 (−) | ++ |
| 47 | Sigma | RECb | Locoreg. | 278.1 (+) | 25.5 (−) | 1.9 (−) | + |
| 48 | Rectum | REC | Locoreg. | 47.4 (+) | 124.2 (+) | 3.9 (−) | + |
| 49 | Rectum | REC | Locoreg. | 3.9 (−) | 9.8 (−) | 2.0 (−) | + |
| 50 | Rectum | REC | Locoreg. | 3.1 (−) | 13.4 (−) | 1.9 (−) | − |
| 51 | Colon | REC | Locoreg. | 0.9 (−) | 127.3 (+) | 104.4 (+) | + |
a Synchronous adenocarcinomas of the right colon and rectum.
b REC, recurrent; Locoreg, locoregional.