Table 1

Cross-resistance patterns of resistant cell lines selected for NB-506

DrugIC50m)a
HCT116HCT116/NR1PC13PC13/NR13LYLY/NR1LY/NR2
NB-5060.13 ± 0.005300 ± 36 (2400)0.23 ± 0.08>1000 (>4300)0.12 ± 0.031.4 ± 0.51 (12)7.7 ± 2.6 (64)
J-1070880.0034 ± 0.000070.78 ± 0.06 (230)0.013 ± 0.0061.8 ± 0.94 (140)0.0017 ± 0.00030.029 ± 0.008 (17)0.36 ± 0.18 (210)
Camptothecin0.0094 ± 0.00060.017 ± 0.005 (1.8)0.038 ± 0.0090.029 ± 0.006 (0.76)0.046 ± 0.0060.058 ± 0.006 (1.3)0.38 ± 0.25 (8.2)
Topotecan0.034 ± 0.0180.14 ± 0.0071 (4.1)0.075 ± 0.0141.1 ± 0.75 (15)0.069 ± 0.0220.25 ± 0.07 (3.6)2.9 ± 1.59 (42)
Etoposide1.1 ± 0.483.4 ± 0.57 (3.1)1.2 ± 0.043.0 ± 2.0 (2.5)0.28 ± 0.080.52 ± 0.19 (1.9)2.0 ± 1.1 (4.7)
Doxorubicin0.025 ± 0.0020.059 ± 0.01 (2.3)0.028 ± 0.0080.069 ± 0.050 (2.5)0.043 ± 0.0020.067 ± 0.007 (1.6)0.19 ± 0.03 (4.5)
Vincristine0.0020 ± 0.00010.0093 ± 0.001 (4.7)0.013 ± 0.0030.0070 ± 0.0020 (0.56)0.015 ± 0.0110.011 ± 0.002 (0.77)0.025 ± 0.014 (1.7)
Paclitaxel0.0011 ± 0.00020.0021 ± 0.0005 (1.9)0.0020 ± 0.00030.0018 ± 0.0012 (0.92)0.041 ± 0.0070.057 ± 0.009 (1.4)0.081 ± 0.036 (2.0)
Mitoxantrone0.0070 ± 0.00230.067 ± 0.035 (9.6)0.033 ± 0.0040.16 ± 0.14 (4.9)0.0045 ± 0.00290.0071 ± 0.0047 (2.2)0.057 ± 0.06 (17)
  • a Values are means ± SE of three independent experiments, with relative resistances indicated in parentheses, which were determined by dividing the IC50 value of the resistant cell line by that of the parental cell line.