Table 2

Evaluation of differentiation markers induced by other signal transduction inhibitors

SKBr-3 cells were treated with the indicated for interventions for 48 h and analyzed. LY294002 (50 μm), PI3 kinase inhibitor; PD 98059 (50 μm), MEK inhibitor; L744832 (20 μm), farnesyltransferase inhibitor 50.
InterventionInduction of MFGM protein (>3-fold)Specific cell cycle arrestLipid induction (X-fold)Morphological differentiation
Control1.0
17-AAG+G15.5Present
Rapamycin+G16.8
Serum starvation+0.9
LY294002+G13.8
PD98059+1.1
L744832+G13.3