Table 1

Bivariate correlations with HIF-1α

HIF-1α staining
FrequencyWeakStrong
No. of patients% of patientsNo. of patients% of patientsNo. of patients% of patientsPrho/ORa
Total9810056573637
Age, yr (median, 57)
 <574849326713270.170.10
 ≥57505124482346
T stage
 1442501250.560.06
 288563338
 3303119631033
 4565730542239
N stage
 03334185514420.52−0.07
 11313754431
 2424324571536
 31010770330
Grade
 Well-differentiated11115466550.01−0.30
 Moderately616233542541
 Poorly differentiated26271869519
Site
 Tonsillar fossa3839246311290.31NA
 Base of tongue293015521241
 Faucial arch21211257943
 Lateral/posterior wall66233467
 Vallecula epiglottica4437500
IMD
 0–8013139692150.480.07
 81–110454622492044
 111–13021211362838
 >13019191263632
Smoking habits
 Nonsmoker12127583250.22NA
 Smoker868849573338
Chemotherapy
 Yes272817638300.66NA
 No717239552839
CR
 Primary tumor
  Yes7981506324300.030.33
  No19196321263
 Lymph nodes
  Yes335122677210.020.34
  No324916501547
Distant metastasis
 Yes14146438570.072.71
 No848650602833
  • a Spearman’s correlation coefficient (rho) was calculated for ordinal parameters; the OR was determined for complete remission and distant metastasis (logistic regression). NA, not applicable.