Table 3

Summary of mutation data

Test of significance: χ2 statistic. Transitions at CpG sites and transversions of all Iranian patients are compared against these mutation classes in ESCC recorded in the database, which at present contains no data from Iran.
A. Iran
No. of patientsPatients with mutationaNo. of p53 mutations identifiedTransitionsTransversionsFrameshifts
MFTotalAt CpG sitesNon-CpG sites
Tehran14264027 (67%)3212 (38%)9 (28%)7 (22%)4 (13%)
Caspian Littoral19153421 (62%)22b8 (36%)6 (27%)3 (14%)6 (27%)
Total334174485420 (37%)15 (28%)10 (19%)10 (19%)
B. IARC database
43068 (16%)107 (25%)180 (41%)75 (18%)
P < 0.0002P < 0.002
  • a Three patients had more than one mutation.

  • b Includes one CT to GC tandem mutation.