Table 2

Genes of up-regulated by PTEN transfer

Clone IDUnigene no.DescriptionPutative functionFold changea
HEC-151HHUAIshikawa
A0493Hs.238990 CDK inhibitor 1B (p27,Kip1, CDKN1B) Cell cycle arrest>1003.66.8
A0485Hs.72901CDK inhibitor 2B (p15,INK4B,CDKN2B)Cell cycle arrest>1002.94.4
A1775Hs.183874 Cullin 4A (CUL4A) Cell cycle arrest23.31.2(−)b
A1778Hs.77054 B-cell translocation gene 1 (BTG1) Cell cycle arrest (tob family)>1002.06.5
A2469Hs.118442 Cyclin C (CCNC) Cell cycle arrest (target genes of VD)3.10.8(−)
A1800Hs.77313 Cyclin-dependent kinase 10 (CDK10) Cell cycle3.32.28.7
A4817Hs.20938 RNA-binding protein (SCR3) Fundamental function (translation)2.82.71.4
A2278Hs.49007 Poly(A) polymerase (PAP) Fundamental function (RNA processing)>1001.31.8
A2519Hs.3530 TLS-associated serine-arginine protein (TASR) Fundamental function (RNA processing)8.80.91.2
A1421Hs.79658 Casein kinase I epsilon (CSNK1E) Fundamental function (DNA replication and repair)2.62.22.1
A4659Hs.8997 Heat shock 70kD protein 1 (HSPA1A) Fundamental function (inhibition of protein degradation)3.78.01.4
A4602Hs.4147 Translocating chain-associating membrane protein (TRAM) Fundamental function (protein translocation)3.71.40.9
A4329Hs.92962 Sec23 homolog A (SEC23A) Fundamental function (protein transport)5.91.22.0
A3979Hs.139336 ATP-binding cassette member 4 (ABCC4) Fundamental function (anion transporter)87.31.80.9
A1348AF065164c Hyperpolarization-activated channel 2 (HCN2) Fundamental function (channel)45.85.23.3
A4927Hs.194625 Dynein light intermediate chain 2 (DNCLI2) Fundamental function (motor protein)>1001.81.6
A1703Hs.154546 Syntaxin 5A (STX5A) Fundamental function (vesicle transport)2.81.21.0
A1174Hs.112378 LIM and senescent cell antigen-like domains 1 (LIMS1) Immune response (cell antigen)55.51.61.7
A4683Hs.177559 Interferon γ receptor 2 (IFNGR2) Immune response3.20.91.7
A2244Hs.73895 TNF-receptor superfamily, member 9 (TNFRSF9) Signal transduction (TNF and TNF receptor family)2.12.9(−)
A1281Hs.129844 Decoy receptor 2 (TNFRSF10D) Signal transduction (TNF and TNF receptor family)3.01.51.1
A1095Hs.81791 TNF receptor superfamily member 11b (TNFRSF11B) Signal transduction (TNF and TNF receptor family)>1001.5(−)
A0137Hs.89862 TNFRSF1A-associated via death domain (TRADD) Signal transduction (TNF-associated protein)4.22.11.9
A6286Hs.8375 TNF-receptor-associated factor 4 (TRAF4) Signal transduction (TNF receptor-associated factor)2.31.31.5
A1717Hs.76090 TNF α induced protein 1 (TNFAIP1) Signal transduction (TNF-induced protein)3.41.52.0
A1329Hs.124024 Deltex (DTX1) Signal transduction (notch-signalling pathway)10.032.5>100
A3662Hs.91143 Jagged1 (Alagille syndrome) (JAG1) Signal transduction (notch-signalling pathway)38.41.30.8
A9582Hs.173063 Transducin like enhancer of split 2 (TLE2) Signal transduction (notch-signalling pathway)2.57.85.9
A2748Hs.3260 Presenillin 1 (PSEN1) Signal transduction (notch-signalling pathway)2.71.21.5
A4947Hs.46348 Bradykinin receptor B1 (BDKRB1) Signal transduction (G protein-coupled receptor)2.83.10.7
A5864Hs.183800 Ran GTPase-activating protein 1 (RANGAP1) Signal transduction (small G)6.71.81.8
A4887Hs.37604 Rho GTPase-activating protein 5 (ARHGAP5) Signal transduction (small G)27.71.91.2
A0436Hs.102402 Mad4 homolog (MAD4) Signal transduction (Mad family)2.02.712.9
A5022Hs.153863 MAD homolog 6 (Smad6) (MADH6) Signal transduction (Mad family)3.82.11.7
A0578Hs.171695 Dual specificity phosphatase 1 (DUSP1) Signal transduction (MAP kinase inhibition)3.62.4(−)
A1686Hs.75842 Protein kinase (DYRK1A) Signal transduction (kinase)2.71.21.4
A0964Hs.75339 Inositol polyphosphate phosphatase-like 1 (INPPL1) Signal transduction (phosphatase)2.12.72.1
A1984Hs.155079 Protein phosphatase 2A regulatory subunit B (PPP2R5A) Signal transduction (phosphatase)2.91.21.4
A1270Hs.123085 Chromobox homolog 4 (CBX4) Signal transduction (repressor of protooncogene)3.51.9(−)
A2849Hs.80962 Neurotensin (NTS) Signal transduction (neurotransmitter)24.62.71.2
A1673Hs.75789 Drg1 protein (NDRG1) Signal transduction (potential cancer suppressor gene)3.51.3(−)
A1046Hs.621 Galectin 3 (LGALS3) Signal transduction8.61.11.1
A4601Hs.14601 Haematopoietic lineage cell-specific protein (HCLS1) Signal transduction10.22.11.2
A4733Hs.7879 Interferon-related developmental regulator 1 (IFRD1) Signal transduction3.00.30.7
A3714Hs.112049 SET-binding factor 1 (SBF1) Signal transduction2.61.70.9
A0341Hs.2780jun D (JUND)Transcription factor (negative regulation of cell proliferation)2.52.72.5
A2872Hs.131953 Basic leucine zipper transcription factor (MAFK) Transcription factor19.61.72.5
A0857Hs.1004 Bromodomain-containing protein (BR140) Transcription factor3.22.0(−)
A0551Hs.54473 Cardiac-specific homeo box (CSX) Transcription factor4.11.72.5
A4266Hs.82071 Cbp/p300-interacting transactivator (CITED2) Transcription factor15.61.35.8
A0011Hs.4055 Core promoter element-binding protein (COPEB) Transcription factor6.52.52.2
A0438Hs.1395 Early growth response 2 (EGR2) Transcription factor2.5(−)(−)
A1367Hs.84728 GC-box-binding protein (BTEB2) Transcription factor7.11.7(−)
A4622Hs.184122 General transcription factor II, I (GTF2I) Transcription factor2.82.83.1
A5048Hs.34853 Inhibitor of DNA-binding 4 (ID4) Transcription factor19.1(−)11.2
A1923Hs.78788 Leucine zipper like transcriptional regulator 1 (LZTR1) Transcription factor2.91.91.7
A0121Hs.167923 MADS box transcription enhancer factor 2 (MEF2D) Transcription factor5.32.0(−)
A2006Hs.79334 Nuclear factor, interleukin 3-regulated (NFIL3) Transcription factor4.80.51.5
A3745Hs.144630 Nuclear receptor subfamily 2 (NR2F1) Transcription factor4.41.21.6
A2703Hs.2982 Sp4 transcription factor (SP4) Transcription factor10.12.42.6
A1618Hs.83484 SRY (sex-determining region Y) box 4 (SOX4) Transcription factor4.25.62.7
A4050Hs.82037 TBP-associated factor (TAF2J) Transcription factor23.6(−)1.3
A2973Hs.123057 TBP-associated factor (TAF2K) Transcription factor2.72.01.4
A1873Hs.169832 Zinc finger protein 42 (ZNF42) Transcription factor3.73.02.8
B5101Hs.9028 Histone deacetylase 5 (NY-CO-9) Transcriptional regulator (chromatin remodelling)2.732.010.2
A3992Hs.239894 Leucine-rich repeat interacting protein 1 (LRRFIP1) Transcription repressor2.71.10.5
A4009Hs.78183 Aldo-keto reductase family 1 (AKR1C3) Metabolic enzyme4.51.60.4
A1212Hs.198365 2,3-bisphosphoglycerate mutase (BPGM) Metabolic enzyme6.41.21.6
A1494Hs.121576 Aspartate β-hydroxylase (ASPH) Metabolic enzyme3.4(−)(−)
A2568U62389c Isocitrate dehydrogenase Metabolic enzyme>1000.6(−)
A2121Hs.771 Liver glycogen phosphorylase (PYGL) Metabolic enzyme4.12.83.6
A1154Hs.82568 Sterol 27-hydroxylase (CYP27A1) Metabolic enzyme19.7(−)(−)
A3744Hs.155455 Liver phosphofructokinase (PFKL) Metabolic enzyme2.71.31.5
A4848Hs.185973 Membrane fatty acid desaturase (MLD) Metabolic enzyme6.02.21.5
A1610Hs.172153 Plasma glutathione peroxidase 3 (GPX3) Catalytic enzyme (detoxification of hydrogen peroxide)12.3(−)3.5
A2378Hs.77502 Methionine adenosyltransferase II α (MAT2A) Catalytic enzyme3.92.11.7