Table 3

Genes of down-regulated by PTEN transfer

Clone IDUnigene no.DescriptionPutative functionFold changea
A0157Hs.23960 Cyclin B1 (CCNB1) Cell proliferation0.230.590.52
A0354Hs.92374 Cyclin G1 interacting protein (cg11) Cell proliferation0.200.74(−)b
A0480Hs.77550 CDC28 protein kinase 1 (CKS1) Cell proliferation0.120.370.60
A0499Hs.83758 CDC28 protein kinase 2 (CKS2) Cell proliferation0.030.440.57
A0245Hs.82906 Cell division cycle 20 (CDC20) Cell proliferation0.060.510.52
A0249Hs.227789 Mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3) Cell proliferation0.240.190.38
A0333Hs.179718 V-myb avian myeloblastosis viral oncogene homolog-like 2 (B-myb, MYBL2) Cell proliferation0.270.460.76
A2369Hs.77597 Polo (Drosophia)-like kinase (PLK) Cell proliferation0.300.510.30
A2506Hs.15243 Nucleolar protein 1 (P120 antigen, NOL1) Cell proliferation0.331.000.00
A2452Hs.108080 Cysteine and glycine-rich protein 1 (CSRP1) Cell proliferation0.390.930.60
A5651Hs.5181 Proliferation-associated 2G4 (PA2G4) Cell proliferation0.250.470.49
A0018Hs.48915 Serine/threonine kinase 15 (STK15) Cell proliferation (centrosome-associated kinase)0.490.650.23
A4854Hs.180655 Serine/threonine kinase 12 (AIM-1, STK12) Cell proliferation (cell division, chromosome segregation)0.150.570.63
A1216Hs.84746 Chromosome condensation 1 (RCC1, CHC1) Cell proliferation (cell division)0.370.650.90
A2154Hs.2934 Ribonucleotide reductase M1 polypeptide (RR1, RRM1) Cell proliferation (cell division)0.450.431.15
A0106Hs.165950 Fibroblast growth factor 4 (FGFR4) Cell proliferation (growth factor)0.191.792.25
A0682Hs.104 Hepatocyte growth factor (HGF) activator (HGFAC) Cell proliferation (growth factor activator)0.21(−)(−)
A0080Hs.78202 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a member 4 (SMARCA) Cell proliferation and transcription0.311.090.85
A1970Hs.79078 MAD2-like 1 (MAD2L1) Fundamental function (cell cycle checkpoint)0.000.460.57
A4383Hs.25292 Ribonuclease H1 large subunit (RNASEHI) Fundamental function (DNA replication and repair)0.340.550.52
A5087Hs.74598 Polymerase δ 2 regulatory subunit (POLD2) Fundamental function (DNA replication and repair)0.260.520.49
A4259Hs.105465 Small nuclear ribonucleoprotein polypeptide F (SNRPF) Fundamental function (RNA processing)0.300.700.75
A2268Hs.63525 Poly(rC)-binding protein 2 (PCBP2) Fundamental function (post-translationally modification by phosphorylation)0.360.480.53
A1825Hs.77522 Major histocompatibility complex class II DM α (HLA-DMA) Immune response0.190.00(−)
A0378Hs.394 Adrenomedullin (ADM) Signal transduction0.060.120.24
A1824Hs.77515 Inositol 1,4,5-triphosphate receptor type 3 (ITPR3) Signal transduction0.251.191.61
A5155Hs.75545 Interleukin 4 receptor (IL4R) Signal transduction0.180.68(−)
A1933Hs.130227 Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) Signal transduction (TNF and TNF receptor family)0.381.71(−)
A3058Hs.239 Forkhead box M1 (M phase phosphoprotein 2) (FKHL16, FOXM1) Signal transduction (regulation of transcription, Forkhead gene family)0.000.440.65
A4228Hs.251238 DR1-associated protein 1 (DRAP1) Signal transduction (repressor of transcription)0.390.670.85
A0492Hs.89657 TBP-associated factor (TAF2H) Transcription factor0.340.740.68
A2776Hs.76362 General transcription factor IIA 1 (GTF2A1) Transcription factor0.420.540.00
A3049Hs.166 Sterol regulatory element binding transcription factor 1 (SREBP-1, SREBF1) Transcription factor0.371.210.77
A5119AF077740c 2-Amino-3-ketobutyrate-CoA ligase Metabolic enzyme0.110.840.74
A2936Hs.83393 Cystatin E/M (CST6) Metabolic enzyme inhibitor0.250.000.84
A0904Hs.75105 Emopamil-binding protein (EBP) Metabolic enzyme0.000.500.38
A3036Hs.154890 Fatty-acid-coenzyme A ligase (FACL2) Metabolic enzyme0.251.101.19
A0688Hs.135 γ-glutamyltransferase 1 (GGT1) Metabolic enzyme0.340.88(−)
A3929Hs.105435 GDP-mannose 4,6-dehydratase (GMDS) Metabolic enzyme0.290.850.19
A0800Hs.772 Glycogen synthase 1 (GYS1) Metabolic enzyme0.410.510.74
A4981Hs.51043 Hexosaminidase B (HEXB) Metabolic enzyme0.400.551.08
A4699Hs.3828 Mevalonate decarboxylase (MVD) Metabolic enzyme0.070.930.24
A3795Hs.118721 Neuraminidase 1 (NEU1) Metabolic enzyme0.440.900.32
A2164Hs.1869 Phosphoglucomutase 1 (PGM1) Metabolic enzyme0.100.410.66
A0899Hs.75093 Procollagen-lysine 2-oxoglutarate 5-dioxygenase (PLOD) Metabolic enzyme0.350.590.63
A3469Hs.111024 Solute carrier family 25 member 1 (SLC25A1) Metabolic enzyme0.300.760.97
A0833Hs.878 Sorbitol dehydrogenase (SORD) Metabolic enzyme0.140.440.73
A0439Hs.388 Nudix-type motif 1 (8-oxo-dGTPase, NUDT1) Catalytic enzyme (prevents mutation)0.470.880.82
A2832Hs.80986 ATP synthase H+ transporting mitochondrial F0 complex subunit c isoform 1 (ATP5G1) Production of biochemical energy0.170.560.38
A2930Hs.85539 ATP synthase H+ transporting mitochondrial F0 complex subunit e (ATP5I) Production of biochemical energy0.180.560.55
A4132Hs.153028 Cytochrome b-561 (CYB561) Production of biochemical energy0.020.600.09
A2770Hs.181028 Cytochrome c oxidase subunit Va subunit (COX5A) Production of biochemical energy0.350.560.76
A2931Hs.81097 Cytochrome c oxidase subunit VIII (COX8) Production of biochemical energy0.280.630.61
A4177Hs.109760 NADH dehydrogenase 1 β subcomplex 3 (NDUFB3) Production of biochemical energy0.400.690.75
A2943Hs.84549 NADH dehydrogenase 1 subcomplex unknown 1 (NDUFC1) Production of biochemical energy0.340.440.71
A5677Hs.5273 NADH dehydrogenase Fe-S protein 3 (NDUFS3) Production of biochemical energy0.290.810.67
A4248Hs.109059 Ribosomal protein mitochondrial L12 (RPML12) Production of biochemical energy0.460.630.54
A4693Hs.18141 Ladinin 1 (LAD1) Cell structure (component of basement membrane)0.230.830.74
A0124Hs.78452 Solute carrier family 20 member 1 (SLC20A1) Other (phosphate transporter)0.351.000.75
A4686Hs.169900 Poly(A)-binding protein, cytoplasmic 4 (PABPC4) Other (pseudogene)0.430.730.41
A2518Hs.106283 Insulin-like growth factor-binding protein 6 (IGFBP6) Growth inhibitor0.111.09(−)
A4234Hs.14623 Interferon γ-inducible protein 30 (IFI30) Unknown (interferon-induced protein)