Summary of MSI and immunohistochemical analysis on control and refractory GCT
| Unselected (n = 100) | Refractory (n = 11) | Pa | |
|---|---|---|---|
| MSI | 6 (6%) | 5 (45%) | 0.001b |
| MSI in 1 of 8 loci | 6 (6%) | 1 (9%) | 0.558b |
| MSI in ≥2 of 8 loci | 0 | 4 (36%) | <0.001b |
| IHCc negative/weak any marker | 3 (3%) | 4 (36%) | |
| hMMLH1 | 0 | 4 (36%) | |
| hMMSH2 | 2 (2%) | 1 (9%) | |
| hMMSH6 | 2 (2%) | 1 (9%) | |
| MSI correctly predicted by IHC | 2 | 3 | |
| MSI not predicted by IHC | 4 | 2 | |
| MSI falsely predicted by IHC | 1 | 1 |
a Ps are given for differences between all tumors of the two study groups as determined by a two-sided Fisher’s exact test.
b Analyzing only the nonseminomas of both groups, the Ps are 0.002, 0.508, and <0.001, respectively.
c IHC, immunohistochemistry.