Table 2

RNA was extracted from 25 human renal tumours of various histological types and from paired normal renal tissue. Expression of HIF-1α and HIF-2α mRNA was determined by RNase protection.

Tumor type (no. of cases assessed/total no. of cases)HIF-1αHIF-2α
No. of cases showing induction of RNA (i.e., tumor >normal)Fold induction (tumor vs. normal) Mean (SD)No. of cases showing induction of RNA (i.e., tumor >normal)Fold induction (tumor vs. normal) Mean (SD)
Clear cell (17/34)12/172.3 (2.5)17/175.2 (5.7)
Papillary (4/5)4/48.7 (10.0)0/40.8 (0.3)
Chromophobe (3/4)2/32.5 (2.2)0/30.9 (0.3)
Collecting duct (1/1)1/14.3 (n/a)0/10.5 (n/a)
Oncocytoma (0/1)Not doneNot doneNot doneNot done