Table 1

Summary of prostatic epithelial defects in Nkx3.1 mutant mice

A. Analysis of mice from 1–24 months in a mixed strain background (C57BI/6J/129/SvImJ)a
GenotypeTotalNormalHyperplasiaPIN
+/+
 1–6 month111100
 6–12 month6411
 12–24 month11920
282431
+/−
 1–6 month12930
 6–12 month7223
 12–24 month11344
301497
−/−
 1–6 months13256
 6–12 month9315
 12–24 month160511
3851122
B. Analysis of mice at 12–15 months in four strain backgrounds
Strain and genoptypeTotalNormalHyperplasiaPIN
C57BI/6J/129/SvImJ
 +/+3300
 +/−3210
 −/−3003
C57BI/6J
 +/+5500
 +/−5230
 −/−6015
FVB/N
 +/+5500
 +/−12453
 −/−5014
129/SvImJ
 +/+3300
 +/−4130
 −/−4031
  • a Data for the mice at 1–12 months include data reported previously by Bhatia-Gaur et al. (6) .