Table 2

Detection of HCMV nucleic acids in different-grade gliomas, meningiomas, other CNS diseases, and normal brain

ISH results with two different HCMV probes are shown. HCMV nucleic acids were detected in glioma specimens but not in normal brain nor in other CNS diseases. HSV-1/2 probe was negative in tumor and normal brain and positive in HSV-1-infected tissue (not shown).

Biotinylated oligo probe specific forHCMV digoxigenin-labeled total genome DNA probe for HCMV
HCMV RNAHSV-1/2
Glioblastoma8/80/34/4
Grade II astrocytoma2/20/22/2
Normal brain0/40/30/4
Meningioma0/5
Stroke0/1
Alzheimer’s0/2
Paraneoplastic encephalitis0/1
Cryptococcal cerebritis0/1