Table 2

RASSF1A inactivation in prostate cell lines

Sample nameImmortalizationTumorigenicityRASSF1A MethylationRASSF1A ExpressionRASSF1A Mutations
RC-114TNoND,a tumor cellsND+None
RC-123TNoND, tumor cellsNDND
RC-123NNoND, normal PrECND+ND
Clonetics PrSCNoND, normal cells+ND
Clonetics PrECNoND, normal cells+ND
DU 145SpontaneousTumorigenic+ND
LNCaPSpontaneousTumorigenic+ND
PC-3SpontaneousTumorigenic+ND
22Rv1SpontaneousTumorigenic+ND
ND-1SpontaneousTumorigenic+ND
RC-58T/hTERThTERTND, tumor originNDND
RC53T/E6E7By HPVND, tumor originND+None
1512TBy HPVND, tumor origin+ND
1512NBy HPVND, from PrEC+ND
1542TBy HPVND, tumor origin+ND
1542NBy HPVND, from PrEC+ND
1550TBy HPVND, tumor origin+ND
1550NBy HPVND, from PrEC+ND
HPV18 C-1By HPVNontumorigenicND+ND
Ki-ras/HPV18 C-1By HPVTumorigenicND+None
129NU5002-1By HPVTumorigenicND+None
  • a ND, not determined; PrSC, normal human prostate stromal cell; PrEC, normal human prostate epithelial cell.