Table 1

β-catenin exon 3 mutations in gastric cancer

SampleCodonMutationAmino acid changeHistologyLocation of mutation relative to phosphorylation site
18ATG → ATAMet → IleDiffuseNone
211GAC → AACAsp → AspIntestinalNone
413GCC → ACCAla → ThrDiffuseNone
521GCT → ACTAla → ThrIntestinalNone
624CAC → TACHis → TyrIntestinalNone
725TGG → TTGTrp → LeuIntestinalNone
828CAG → TAGGln → StopDiffuseAdjacent
929TCT → GCTSer → AlaIntestinalPhosphorylation site
1032GAC → TACAsp → TyrIntestinalAdjacent
1132GAC → AACAsp → AspDiffuseAdjacent
1237TCT → TTTSer → PheIntestinalPhosphorylation site
1337TCT → GCTSer → AlaDiffusePhosphorylation site
13a55GAG → GGGGlu → GlyDiffuseNone
14b37TCT → GCTSer → AlaDiffusePhosphorylation site
1537TCT → GCTSer → AlaIntestinalPhosphorylation site
1639GCC → GGCAla → GlyDiffuseAdjacent
1747AGT → ACTSer → ThrDiffusePhosphorylation site
1848GGT → GTTGly → ValIntestinalAdjacent
19c25TGG → TTGTrp → LeuIntestinalNone
37TCT → GCTSer → AlaIntestinalPhosphorylation site
48GGT → GTTGly → ValIntestinalAdjacent
  • a Sample was a metastasis from primary tumor 13.

  • b Sample was a metastasis; primary tissue was unavailable.

  • c Multiple foci were analyzed within the same tumor.