Table 1

Metastases that regressed completely in response to therapy

The number following P refers to patient’s identity. The following letter (a, b, …) identifies individual metastasis. The following number codes the relationship between FNA and treatment (0, pretreatment; 1, first and 2, second biopsy after treatment. Size of tumor, two ortogonal diameters. Time of FNA in relation to treatment (pre versus post). Treatment type, melanoma antigen targeted by the immunization. Systemic IL-2 corresponds to 720,000 IU/kg every 8 h to limit toxicity.

Case no.Sex/AgeFNA siteDate of FNASize of metastasisTime of FNATreatment typeSystemic IL-2 administrationDate of last follow-upSize at last follow-upSource total RNA (μg)aRNA yield (μg)
P1-a0-crM/34R Groin10/7/19991 × 1PreMART-1/GPyes2/29/20000087
P1-a1-crM/34R Groin12/2/19991.5 × 1.5PostMART-1/GPyes2/29/20000048
P2-a0-crM/52L Parotid6/22/19991.5 × 1.5PreTRP-1yes10/15/1999017149
P2-a1-crM/52L Parotid8/6/19992 × 2PostTRP-1yes10/15/1999014140
P3-a0-crM/31L Axilla2/5/19992 × 2PreTRP-1yes4/1/199901073
P6-a0-crM/49L Lat Knee2/23/19992.5 × 2.5PreGPyes7/29/199902125
P6-a1-crM/49L Lat Knee6/29/19993 × 2.5PostGPyes7/29/199904145
P6-b0-crM/49L Med Knee2/23/19991.5 × 1.5PreGPyes7/29/20000370
P6-b1-crM/49L Med Knee6/29/19991 × 1PostGPyes7/29/200003195
P10-a0-crM/67L Neck3/17/19992 × 2PreGPno8/31/1999027103
P10-a1-crM/67L Neck7/1/19992 × 3PostGPno8/31/19990196
P14-a0-crM/49R Face Inf4/6/19991 × 2PreGPyes8/11/199905115
P14-a1-crM/49R Face Inf7/1/19992 × 2PostGPyes8/11/19990177
P14-b0-crM/49R Face Sup3/19/19992 × 2PreGPyes8/11/19990192
P14-b1-crM/49R Face Sup7/1/19992 × 2PostGPyes8/11/19990120
P16-a0-crM/62R Chest4/27/19991 × 1.5PreMART-1yes9/1/199907134
P16-a1-crM/62R Chest6/10/19991.5 × 1.5PostMART-1yes9/1/1999012143
P18-a0-crF/65L Neck6/8/19992 × 2PreGPyes8/31/19990451
P18-b0-crF/65R Neck6/8/19993 × 3PreGPyes8/31/19990537
P21-a0-crF/35L Temple9/21/19991 × 1.5PreGP (cells)no11/3/199909011
P23-a0-crM/53R Thigh Dist6/22/19992.5 × 2.5PreMART-1yes1/6/20000352
P23-a1-crM/53R Thigh Low9/30/19991 × 1.5PostMART-1yes1/6/20000384
P23-b1-crM/53R Thigh Prox9/30/19991.5 × 2PostMART-1yes1/6/2000029
Metastases that regressed partially in response to therapy
P4-b0-prM/67R Knee3/11/19991 × 1PreGPyes7/7/19990.5 × 0.523147
P4-b1-prM/67R Knee6/22/19990.5 × 0.5PostGPyes7/7/19990.5 × 0.55116
P20-a0-prM/54R Groin7/27/19994 × 4PreMART-1/GPno9/7/19992 × 34341
P20-a1-prM/54R Groin9/7/19992 × 3PostMART-1/GPno9/7/19992 × 3825
Metastases that remained stable during the observation period
P4-a0-sdM/67R Prox Leg3/11/19992 × 2PreGPyes7/7/19991.5 × 1.55116
P4-a1-sdM/67R Prox Leg6/22/19991.5 × 1.5PostGPyes7/7/19991.5 × 1.5592
P5-a0-sdF/58L Groin7/28/19991 × 1PreGP-T cellsno10/14/19991.5 × 1.00118
P5-a1-sdF/58L Groin8/23/19991.5 × 1.5PostGP-T cellsno10/14/19991.5 × 1.0033
P5-b0-sdF/58L Leg7/28/19991 × 2PreGP-T cellsno10/14/19992 × 22150
P5-b1-sdF/58L Leg8/23/19992 × 2PostGP-T cellsno10/14/19992 × 2285
P8-b0-sdM/74R Arm6/29/19993 × 3PreGPno8/17/19993 × 3.52147
P8-b1-sdM/74R Arm8/17/19993 × 3.5PostGPno8/17/19993 × 3.514166
P13-a0-sdM/58R Arm Inf9/9/19992 × 2PreGPno12/7/19992 × 2.53101
P13-a1-sdM/58R Arm Inf12/7/19992 × 2.5PostGPno12/7/19992 × 2.510115
P13-b0-sdM/58R Arm Sup9/9/19992 × 2PreGPno12/7/19992.5 × 3.518138
P21-b0-sdF/35R Occipital9/21/19992.5 × 3PreGP (cells)no11/3/19993 × 3.530124
P21-b1-sdF/35R Occipital11/3/19993 × 3.5PostGP (cells)no11/3/19993 × 3.537102
P22-a0-sdM/32R Leg4/29/19992 × 2PreMART-1/GPno7/1/19992 × 2862
Metastases that did not respond to therapy
P7-a0-nrF/76L Breast6/10/19991 × 2PreGPno7/27/19992 × 20116
P8-a0-nrM/74Abdomen6/29/19994 × 6PreGPno8/17/19997 × 7265
P8-a1-nrM/74Abdomen8/17/19997 × 7PostGPno8/17/19997 × 71457
P9-a0-nrF/59L Scalp1/5/19991 × 1PreGPyes3/1/93993 × 33241
P11-a0-nrM/48R Neck5/27/19992.5 × 3PreGPyes10/14/19999 × 10941
P11-a1-nrM/48R Neck7/13/19996 × 10PostGPyes10/14/19999 × 1056149
P12-a0-nrF/58R Thigh Dist5/27/19991 × 1PreGPyes9/3/19992 × 20102
P12-a1-nrF/58R Thigh Dist9/3/19992 × 2PostGPyes9/3/19992 × 2198
P12-b0-nrF/58Epigastric5/27/19991.5 × 1.5PreGPyes9/3/19994 × 47129
P12-b1-nrF/58Epigastric9/3/19994 × 4PostGPyes9/3/19994 × 414102
P12-c0-nrF/58R Thigh Prox5/27/19993 × 3PreGPyes12/15/199911.5 × 1313149
P12-c1-nrF/58R Thigh Prox9/3/199910 × 13PostGPyes12/15/199911.5 × 1313128
P15-a1-nrM/55L Chest1/21/19991 × 1PostGPyes3/4/19992 × 2016
P17-a0-nrM/52L Supraclav6/15/19991 × 2PreGPyes9/30/19993 × 3.52149
P17-a1-nrM/52L Supraclav9/30/19993.0 × 3.5PostGPyes9/30/19993 × 3.53111
P19-a0-nrM/50T Chest3/11/19993 × 4PreGPyes5/28/19998 × 8216
P24-a0-nrF/32R Back6/28/19992 × 2Prenoneyes8/31/19994 × 519113
P24-a1-nrF/32R Back8/31/19994 × 4Postnoneyes8/31/19994 × 528202
P25-a1-nrF/51L Abdomen8/24/19992 × 2.5Postnoneyes12/16/19994 × 5277
P25-a2-nrF/51L Abdomen12/16/19994 × 5Postnoneyes12/16/19994 × 5591
P25-b0-nrF/51R Abdomen3/30/19992 × 3Prenoneyes12/16/19996 × 87118
P25-b1-nrF/51R Abdomen12/16/19996 × 8Postnoneyes12/16/19996 × 827130