Table 2

Primary 4T1 mammary tumors grow slightly faster in BALB/c.IFNγ−/− mice as compared with wild-type BALB/c mice; however, growth is not affected by depletion of CD4, CD8, NK, or phagaocytic cells

Mice were inoculated s.c. in the abdominal mammary gland with 7 × 103 4T1 cells. Primary tumors were measured every 3–4 days. Numbers in parentheses indicate the number of mice per group. Two separate experiments are shown.

StrainTumor onset (days)Tumor diameter at day 35 (mm)
BALB/c (25)6–138.5 ± 1.4
BALB/c.IFNγ−/− (11)7–109.5 ± 1.3a
BALB/c (27)7–129.3 ± 1.5
BALB/c.Pfp−/− (8)10–128.5 ± 0.4b
anti-asialo GM1 (8)7–99.5 ± 1.1
CD4-depleted (9)7–109.2 ± 0.9
CD8-depleted (10)10–148.5 ± 1.3
Carrageenan (9)7–119.0 ± 0.7
  • a Statistically significantly different from that of control BALB/c mice (P < 0.05).

  • b Statistically significantly different from that of control BALB/c mice (P < 0.025).