Table 2

Up-regulated genes expressed at least 2-fold higher (P < 0.01a) in clear cell OvCa compared with other histological types

Gene symbolMean fold changeAve.DescriptionNCBI locus link
Cbvs. MC vs. EC vs. S
Stress response
GPX320.2315.586.7812.88Glutathione peroxidase 3 (plasma)2878
GLRX5.345.978.076.36Glutaredoxin (thioltransferase)2745
LBP4.206.076.075.37Lipopolysaccharide-binding protein3929
CRYAB4.503.512.513.41Crystallin, α B1410
DEFB12.533.324.413.33Defensin, β 11672
HCLS13.263.343.393.33Hematopoietic cell-specific Lyn substrate 13059
SOD23.222.792.602.86Superoxide dismutase 2, mitochondrial6648
HSPA22.452.132.602.38Heat shock 70kD protein 23306
ORM12.332.242.322.30Orosomucoid 15004
Cell proliferation/differentiation, hormones, receptors
CSPG211.9613.408.7311.18Chondroitin sulfate proteoglycan 2 (versican)1462
IGFBP15.846.527.426.57Insulin-like growth factor binding protein 13484
PTHLH5.955.967.106.31Parathyroid hormone-like hormone5744
TCF23.916.838.696.15Transcription factor 2, hepatic; LF-B36928
DRIL15.403.895.064.74Dead ringer (Drosophila)-like 11820
GPC34.055.154.864.66Glypican 32719
IGFBP35.063.865.044.62Insulin-like growth factor binding protein 33486
TOB12.404.316.184.00Transducer of ERBB2, 110140
MITF2.803.524.853.63Microphthalmia-associated transcription factor4286
NDRG13.034.373.183.48N-myc downstream regulated10397
NR1H42.393.613.883.23Nuclear receptor subfamily 1, group H, member 49971
FGFR32.213.863.703.16Fibroblast growth factor receptor 32261
PVR2.233.363.532.98Poliovirus receptor5817
PIG72.672.973.192.93LPS-induced TNF-α factor9516
IL62.472.902.822.72Interleukin 6 (IFN, β 2)3569
PTPRM2.962.462.632.67Protein tyrosine phosphatase, receptor type, M5797
FOXO1A2.012.672.882.49Forkhead box O1A (rhabdomyosarcoma)2308
ERBB22.402.552.532.49v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 22064
C5R12.032.822.682.48Complement component 5 receptor 1 (C5a ligand)728
MIG23.052.472.012.48Mitogen inducible 210979
PRX22.132.432.152.23Paired related homeobox protein51450
Extracellular matrix, cytoskeletal, cell adhesion
NID24.358.569.777.14Nidogen 222795
LAMB13.616.279.946.08Laminin, β 13912
COMP7.546.093.995.68Cartilage oligomeric matrix protein (pseudoachondroplasia)1311
MAGP25.024.022.523.70Microfibril-associated glycoprotein-28076
PLS32.084.834.873.66Plastin 3 (T isoform)5358
MCAM2.513.285.573.58Melanoma adhesion molecule4162
SPP16.012.832.173.33Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I)6696
LAMC13.302.762.332.77Laminin, γ 1 (formerly LAMB2)3915
COL4A22.722.582.832.71Collagen, type IV, α 21284
E482.292.692.932.62Lymphocyte antigen 6 complex, locus D8581
PSCDBP2.442.322.322.36Pleckstrin homology, Sec7 and coiled/coil domains, binding protein9595
COL4A12.432.122.532.35Collagen, type IV, α 11282
MYOC2.172.212.272.22Myocilin, trabecular meshwork inducible glucocorticoid response4653
Proteases, protease inhibitors, enzyme inhibitors
ANXA42.119.6712.566.36Annexin A4307
TFPI24.904.085.904.90Tissue factor pathway inhibitor 27980
CST63.954.103.343.78Cystatin E/M1474
SLPI3.393.492.142.94Secretory leukocyte protease inhibitor (antileukoproteinase)6590
TIMP22.232.542.022.25Tissue inhibitor of metalloproteinase 27077
CPM2.122.082.292.16Carboxypeptidase M1368
Metabolism, catabolism
GGT15.786.597.236.51Gamma-glutamyltransferase 12678
NNMT7.485.624.335.67Nicotinamide N-methyltransferase4837
MAL10.675.862.565.43Mal, T-cell differentiation protein4118
EEF1A22.784.815.094.09Eukaryotic translation elongation factor 1 α 21917
HGD2.443.726.713.93Homogentisate 1,2-dioxygenase (homogentisate oxidase)3081
TCN23.222.884.473.46Transcobalamin II; macrocytic anemia6948
CDA2.853.643.773.40Cytidine deaminase978
PCCA3.012.584.853.35Propionyl Coenzyme A carboxylase, α polypeptide5095
CRYM2.193.194.313.11Crystallin, μ1428
PDXK3.152.703.213.01Pyridoxal (pyridoxine, vitamin B6) kinase8566
CYP1B13.263.182.522.96Cytochrome P450, subfamily I (dioxin-inducible), polypeptide 11545
STC12.962.064.252.96Stanniocalcin 16781
NP2.282.773.992.93Nucleoside phosphorylase4860
WARS2.732.122.402.40Tryptophanyl-tRNA synthetase7453
HMOX12.052.152.372.18Heme oxygenase (decycling) 13162
Transporters, carriers, trafficking
FXYD218.3934.4338.8929.09FXYD domain-containing ion transport regulator 2486
RBP414.1525.5129.4722.00Retinol-binding protein 4, interstitial5950
SLC6A123.313.192.522.99Solute carrier family 6, member 126539
VATI2.782.512.482.59Membrane protein of cholinergic synaptic vesicles10493
GP36B2.472.932.152.50Endoplasmic reticulum glycoprotein10960
RAB92.272.672.532.48RAB9, member RAS oncogene family9367
KDELR32.602.442.042.35KDEL endoplasmic reticulum protein retention receptor 311015
Function not well elucidated
C3F2.402.352.242.33Putative protein similar to nessy (Drosophila)10162
ITM2B2.102.112.002.07Integral membrane protein 2B9445
  • a Significance for fold change determined using the Student t test by comparing clear cell samples with all other groups combined.

  • b C, clear cell; M, mucinous; E, endometrioid; S, serous; Ave., average; NCBI, National Center for Biotechnology Information.