Up-regulated genes expressed at least 2-fold higher (P < 0.01a) in clear cell OvCa compared with other histological types
| Gene symbol | Mean fold change | Ave. | Description | NCBI locus link | ||
|---|---|---|---|---|---|---|
| Cbvs. M | C vs. E | C vs. S | ||||
| Stress response | ||||||
| GPX3 | 20.23 | 15.58 | 6.78 | 12.88 | Glutathione peroxidase 3 (plasma) | 2878 |
| GLRX | 5.34 | 5.97 | 8.07 | 6.36 | Glutaredoxin (thioltransferase) | 2745 |
| LBP | 4.20 | 6.07 | 6.07 | 5.37 | Lipopolysaccharide-binding protein | 3929 |
| CRYAB | 4.50 | 3.51 | 2.51 | 3.41 | Crystallin, α B | 1410 |
| DEFB1 | 2.53 | 3.32 | 4.41 | 3.33 | Defensin, β 1 | 1672 |
| HCLS1 | 3.26 | 3.34 | 3.39 | 3.33 | Hematopoietic cell-specific Lyn substrate 1 | 3059 |
| SOD2 | 3.22 | 2.79 | 2.60 | 2.86 | Superoxide dismutase 2, mitochondrial | 6648 |
| HSPA2 | 2.45 | 2.13 | 2.60 | 2.38 | Heat shock 70kD protein 2 | 3306 |
| ORM1 | 2.33 | 2.24 | 2.32 | 2.30 | Orosomucoid 1 | 5004 |
| Cell proliferation/differentiation, hormones, receptors | ||||||
| CSPG2 | 11.96 | 13.40 | 8.73 | 11.18 | Chondroitin sulfate proteoglycan 2 (versican) | 1462 |
| IGFBP1 | 5.84 | 6.52 | 7.42 | 6.57 | Insulin-like growth factor binding protein 1 | 3484 |
| PTHLH | 5.95 | 5.96 | 7.10 | 6.31 | Parathyroid hormone-like hormone | 5744 |
| TCF2 | 3.91 | 6.83 | 8.69 | 6.15 | Transcription factor 2, hepatic; LF-B3 | 6928 |
| DRIL1 | 5.40 | 3.89 | 5.06 | 4.74 | Dead ringer (Drosophila)-like 1 | 1820 |
| GPC3 | 4.05 | 5.15 | 4.86 | 4.66 | Glypican 3 | 2719 |
| IGFBP3 | 5.06 | 3.86 | 5.04 | 4.62 | Insulin-like growth factor binding protein 3 | 3486 |
| TOB1 | 2.40 | 4.31 | 6.18 | 4.00 | Transducer of ERBB2, 1 | 10140 |
| MITF | 2.80 | 3.52 | 4.85 | 3.63 | Microphthalmia-associated transcription factor | 4286 |
| NDRG1 | 3.03 | 4.37 | 3.18 | 3.48 | N-myc downstream regulated | 10397 |
| NR1H4 | 2.39 | 3.61 | 3.88 | 3.23 | Nuclear receptor subfamily 1, group H, member 4 | 9971 |
| FGFR3 | 2.21 | 3.86 | 3.70 | 3.16 | Fibroblast growth factor receptor 3 | 2261 |
| PVR | 2.23 | 3.36 | 3.53 | 2.98 | Poliovirus receptor | 5817 |
| PIG7 | 2.67 | 2.97 | 3.19 | 2.93 | LPS-induced TNF-α factor | 9516 |
| IL6 | 2.47 | 2.90 | 2.82 | 2.72 | Interleukin 6 (IFN, β 2) | 3569 |
| PTPRM | 2.96 | 2.46 | 2.63 | 2.67 | Protein tyrosine phosphatase, receptor type, M | 5797 |
| FOXO1A | 2.01 | 2.67 | 2.88 | 2.49 | Forkhead box O1A (rhabdomyosarcoma) | 2308 |
| ERBB2 | 2.40 | 2.55 | 2.53 | 2.49 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | 2064 |
| C5R1 | 2.03 | 2.82 | 2.68 | 2.48 | Complement component 5 receptor 1 (C5a ligand) | 728 |
| MIG2 | 3.05 | 2.47 | 2.01 | 2.48 | Mitogen inducible 2 | 10979 |
| PRX2 | 2.13 | 2.43 | 2.15 | 2.23 | Paired related homeobox protein | 51450 |
| Extracellular matrix, cytoskeletal, cell adhesion | ||||||
| NID2 | 4.35 | 8.56 | 9.77 | 7.14 | Nidogen 2 | 22795 |
| LAMB1 | 3.61 | 6.27 | 9.94 | 6.08 | Laminin, β 1 | 3912 |
| COMP | 7.54 | 6.09 | 3.99 | 5.68 | Cartilage oligomeric matrix protein (pseudoachondroplasia) | 1311 |
| MAGP2 | 5.02 | 4.02 | 2.52 | 3.70 | Microfibril-associated glycoprotein-2 | 8076 |
| PLS3 | 2.08 | 4.83 | 4.87 | 3.66 | Plastin 3 (T isoform) | 5358 |
| MCAM | 2.51 | 3.28 | 5.57 | 3.58 | Melanoma adhesion molecule | 4162 |
| SPP1 | 6.01 | 2.83 | 2.17 | 3.33 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I) | 6696 |
| LAMC1 | 3.30 | 2.76 | 2.33 | 2.77 | Laminin, γ 1 (formerly LAMB2) | 3915 |
| COL4A2 | 2.72 | 2.58 | 2.83 | 2.71 | Collagen, type IV, α 2 | 1284 |
| E48 | 2.29 | 2.69 | 2.93 | 2.62 | Lymphocyte antigen 6 complex, locus D | 8581 |
| PSCDBP | 2.44 | 2.32 | 2.32 | 2.36 | Pleckstrin homology, Sec7 and coiled/coil domains, binding protein | 9595 |
| COL4A1 | 2.43 | 2.12 | 2.53 | 2.35 | Collagen, type IV, α 1 | 1282 |
| MYOC | 2.17 | 2.21 | 2.27 | 2.22 | Myocilin, trabecular meshwork inducible glucocorticoid response | 4653 |
| Proteases, protease inhibitors, enzyme inhibitors | ||||||
| ANXA4 | 2.11 | 9.67 | 12.56 | 6.36 | Annexin A4 | 307 |
| TFPI2 | 4.90 | 4.08 | 5.90 | 4.90 | Tissue factor pathway inhibitor 2 | 7980 |
| CST6 | 3.95 | 4.10 | 3.34 | 3.78 | Cystatin E/M | 1474 |
| SLPI | 3.39 | 3.49 | 2.14 | 2.94 | Secretory leukocyte protease inhibitor (antileukoproteinase) | 6590 |
| TIMP2 | 2.23 | 2.54 | 2.02 | 2.25 | Tissue inhibitor of metalloproteinase 2 | 7077 |
| CPM | 2.12 | 2.08 | 2.29 | 2.16 | Carboxypeptidase M | 1368 |
| Metabolism, catabolism | ||||||
| GGT1 | 5.78 | 6.59 | 7.23 | 6.51 | Gamma-glutamyltransferase 1 | 2678 |
| NNMT | 7.48 | 5.62 | 4.33 | 5.67 | Nicotinamide N-methyltransferase | 4837 |
| MAL | 10.67 | 5.86 | 2.56 | 5.43 | Mal, T-cell differentiation protein | 4118 |
| EEF1A2 | 2.78 | 4.81 | 5.09 | 4.09 | Eukaryotic translation elongation factor 1 α 2 | 1917 |
| HGD | 2.44 | 3.72 | 6.71 | 3.93 | Homogentisate 1,2-dioxygenase (homogentisate oxidase) | 3081 |
| TCN2 | 3.22 | 2.88 | 4.47 | 3.46 | Transcobalamin II; macrocytic anemia | 6948 |
| CDA | 2.85 | 3.64 | 3.77 | 3.40 | Cytidine deaminase | 978 |
| PCCA | 3.01 | 2.58 | 4.85 | 3.35 | Propionyl Coenzyme A carboxylase, α polypeptide | 5095 |
| CRYM | 2.19 | 3.19 | 4.31 | 3.11 | Crystallin, μ | 1428 |
| PDXK | 3.15 | 2.70 | 3.21 | 3.01 | Pyridoxal (pyridoxine, vitamin B6) kinase | 8566 |
| CYP1B1 | 3.26 | 3.18 | 2.52 | 2.96 | Cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 | 1545 |
| STC1 | 2.96 | 2.06 | 4.25 | 2.96 | Stanniocalcin 1 | 6781 |
| NP | 2.28 | 2.77 | 3.99 | 2.93 | Nucleoside phosphorylase | 4860 |
| WARS | 2.73 | 2.12 | 2.40 | 2.40 | Tryptophanyl-tRNA synthetase | 7453 |
| HMOX1 | 2.05 | 2.15 | 2.37 | 2.18 | Heme oxygenase (decycling) 1 | 3162 |
| Transporters, carriers, trafficking | ||||||
| FXYD2 | 18.39 | 34.43 | 38.89 | 29.09 | FXYD domain-containing ion transport regulator 2 | 486 |
| RBP4 | 14.15 | 25.51 | 29.47 | 22.00 | Retinol-binding protein 4, interstitial | 5950 |
| SLC6A12 | 3.31 | 3.19 | 2.52 | 2.99 | Solute carrier family 6, member 12 | 6539 |
| VATI | 2.78 | 2.51 | 2.48 | 2.59 | Membrane protein of cholinergic synaptic vesicles | 10493 |
| GP36B | 2.47 | 2.93 | 2.15 | 2.50 | Endoplasmic reticulum glycoprotein | 10960 |
| RAB9 | 2.27 | 2.67 | 2.53 | 2.48 | RAB9, member RAS oncogene family | 9367 |
| KDELR3 | 2.60 | 2.44 | 2.04 | 2.35 | KDEL endoplasmic reticulum protein retention receptor 3 | 11015 |
| Function not well elucidated | ||||||
| C3F | 2.40 | 2.35 | 2.24 | 2.33 | Putative protein similar to nessy (Drosophila) | 10162 |
| ITM2B | 2.10 | 2.11 | 2.00 | 2.07 | Integral membrane protein 2B | 9445 |
a Significance for fold change determined using the Student t test by comparing clear cell samples with all other groups combined.
b C, clear cell; M, mucinous; E, endometrioid; S, serous; Ave., average; NCBI, National Center for Biotechnology Information.