Table 2

DNMT3B genotype and allele frequencies of case patients and control subjects and their association with lung cancer

GenotypesCase patients (n = 319)Control subjects (n = 340)Crude OR (95% CI)Adjusted OR (95% CI)b
No.(%)No.(%)
DNMT3B C46359Ta
 CC (ref.)71(22.3)119(35.0)1.001.00
 CT181(56.7)142(41.8)2.14 (1.48–3.08)2.13 (1.47–3.08)
 TT67(21.0)79(23.2)1.42 (0.92–2.20)1.42 (0.91–2.21)
 CT + TT248(77.7)221(65.0)1.88 (1.33–2.66)1.88 (1.32–2.66)
T allele0.4940.441
  • a χ2 = 17.2, P = 0.0002 (genotype); χ2 = 3.7, P = 0.056 (allele); the observed genotype frequency in the control subjects was in agreement with Hardy-Weinberg equilibrium (p2 + 2pq + q2 = 1) (χ2 = 4.10, P = 0.129).

  • b ORs were adjusted for age, sex, pack-years, and family history of cancer in a logistic regression model.