Table 1

Summary of INK4α/ARF locus alterations in patients with severe dysplasia of the oral cavity

Patient no.GenderLesion siteaLOHbMutationcDeletionMethylationd
p16p142p16p14
1eMaleBuccal mucosa1++
1beMaleBuccal mucosa1
1ceMaleBuccal mucosa0+
2MaleFloor of mouth1+++
3FemalePalate1++
4MalePalatea1++
5MaleFloor of moutha2+++
6FemaleTongue1+
7MaleBuccal mucosa0
8MaleLip1
9MalePalatea1
10MaleBuccal mucosa1+
11MaleFloor of mouth2++
12MaleFloor of mouth2+
13FemaleLip0
14MaleTongue2+
15FemaleFloor of mouth3+
16FemaleTongue1+
17FemaleTonguea0+
18FemaleTongue0+++
19MaleBuccal mucosa0
20FemaleTonguea1
21MaleTonguea1+
22MaleTongue3+
23FemaleTongue0+
24FemaleBuccal mucosa1
25FemaleFloor of mouth2+
26MaleFloor of moutha1
Percentagef76.915.411.57.711.53.857.73.8
  • a Dysplastic lesions with leukoplakia.

  • b LOH indicates the number of positive LOH markers detected per patient sample analyzed.

  • c All mutations detected were in exon 2.

  • d Hypermethylation of p16INK4a correlates with lesions present on the tongue and floor of the mouth and is significantly linked to the presence of LOH in two or more markers (P ≤ 0.01), χ2 test.

  • e Tissue was obtained from the same patient over 3 consecutive years.

  • f Percentage refers to the percentage of patients whose tissue contained the genetic aberration.