Enzyme | ZD1839 IC_{50}^{a} (μm) |
---|---|
TKs | |
EGFR (A431 membrane prep) | 0.033^{b} (0.024–0.059; n = 3) |
EGFR (baculovirus lysate) | 0.027^{b} (0.009–0.054; n = 5) |
erbB2 | 3.7–10 (n = 5) |
KDR | 3.7–10 (n = 2) |
Flt-1 | >100 (n = 2) |
Serine-threonine kinases | |
Raf | >10 (n = 2) |
MEK-1 | >10 (n = 3) |
ERK-2 (MAPK) | >100 (n = 2) |
a n, number of experiments.
b Values are the mean (range).