Table 1

In vitro profile of ZD1839

EnzymeZD1839 IC50am)
TKs
 EGFR (A431 membrane prep)0.033b (0.024–0.059; n = 3)
 EGFR (baculovirus lysate)0.027b (0.009–0.054; n = 5)
 erbB23.7–10 (n = 5)
 KDR3.7–10 (n = 2)
 Flt-1>100 (n = 2)
Serine-threonine kinases
 Raf>10 (n = 2)
 MEK-1>10 (n = 3)
 ERK-2 (MAPK)>100 (n = 2)
  • a n, number of experiments.

  • b Values are the mean (range).