Table 2

Selectivity of ZD1839 in cell proliferation assays

Cell line (stimulus)ZD1839 IC50am)
KB (control)8.8b (8.64–9.03; n = 5)
KB (EGF)0.054b (0.024–0.084; n = 5)
HUVECs (EGF)0.03–0.1
HUVECs (FGF)1–3
HUVECs (VEGF)1–3
  • a n, number of experiments.

  • b Values are the mean (range).