Table 3

Maximum effect of ZD1839 treatment on tumor xenograft growth

Xenograft (origin)Inhibition of tumor volume relative to vehicle controla (%)
KB (oral squamous)62 (P < 0.05)
HX62 (ovary)56 (P < 0.01)
LoVo (colon)80 (P < 0.001)
CR10 (colon)96 (P < 0.01)
HCT15 (colon)56 (P < 0.05)
HT29 (colon)43 (P < 0.001)
MIA PaCa-2 (pancreas)8
MDA-MB-231 (breast)6
MKN45 (gastric)1
  • a Inhibition was measured after 14–28 days of treatment.