Table 1

Outline of experiments

ExperimentGroupVaccinations
123456
1aAHBSSHBSSHBSSHBSS
BV-WT+ rF-GM-CSF+ IL-2FP-WT+ rF-GM-CSF+ IL-2FP-WT+ rF-GM-CSF+ IL-2FP-WT+ rF-GM-CSF+ IL-2
CrV-TRICOM+ rGM-CSF+ IL-2rF-TRICOM+ rF-GM-CSF+ IL-2rF-TRICOM+ rF-GM-CSF+ IL-2rF-TRICOM+ rF-GM-CSF+ IL-2
DrV-CEA/TRICOM+ rGM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2
ErV-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOM
2ArV-CEA/TRICOMrF-CEA/TRICOMHBSSHBSSHBSSHBSS
BrV-CEA/TRICOMrF-CEA/TRICOMrF-CEArF-CEArF-CEArF-CEA
CrV-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOM
3ArV-CEA/TRICOM+ rGM-CSF+ IL-2rF-CEA/TRICOM + rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM + rF-GM-CSF+ IL-2
BrV-CEA/TRICOM+ rGM-CSFrF-CEA/TRICOM+ rF-GM-CSFrF-CEA/TRICOM+ rF-GM-CSFrF-CEA/TRICOM+ rF-GM-CSF
CrV-CEA/TRICOM+ IL-2rF-CEA/TRICOM+ IL-2rF-CEA/TRICOM+ IL-2rF-CEA/TRICOM+ IL-2
DrV-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOMrF-CEA/TRICOM
4ArV-CEA/TRICOM+ rGM-CSF+ IL-2rF-CEA/TRICOM + rF-GM-CSF+ IL-2rF-CEA/TRICOM+ vGM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2
BrF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2rF-CEA/TRICOM+ rF-GM-CSF+ IL-2
CrF-GM-CSF+ IL-2rF-GM-CSF+ IL-2rF-GM-CSF+ IL-2rF-GM-CSF+ IL-2
  • a For certain experiments, it was necessary to compress the vaccination schedule to every 7 days when treating mice bearing 14-day established tumors in order to complete the vaccine regimen. For experiments 1, 3, and 4: CEA-Tg mice were immunized weekly. For experiment 2, CEA-Tg mice were immunized biweekly.