Table 1

Fecal excretion of unchanged drug and metabolites after oral administration of docetaxel (10 mg/kg) with or without concomitant oral cyclosporin A (50 mg/kg) to wild-type and Mdr1a/1b (−/−) mice

Data are expressed as percentage of administered dose ± SE (n = 4).

Mouse strainCyclosporin ADocetaxelMetabolites
Wild-type38.6 ± 2.032.7 ± 2.8
Wild-type+5.4 ± 1.337.3 ± 2.0
Mdr1a/1b (−/−)1.4 ± 0.645.2 ± 2.9
Mdr1a/1b (−/−)+0.1 ± 0.125.8 ± 4.6