Table 2

Comparison of LOH frequencies between treatment groups on commonly targeted chromosomes

TumorChromosome 4Chromosome 12Chromosome 14
SPa30/39 (77%)2/24 (8.3%)4/16 (25%)
NNK18/50 (36%) P < 0.001b8/20 (40%) P < 0.017/22 (32%)
VC30/48 (62%)10/25 (40%) P < 0.014/10 (40%)
  • a SP, spontaneous tumors.

  • b χ2 compares the frequencies in carcinogen-induced tumors (NNK or VC) with the spontaneous tumors.