Table 1

BRAF and KRAS mutations in lung adenocarcinoma

No. of casesBRAF mutationaKRAS mutationbClustercFrequency
Total1272/127 (1.6%)30/89 (33.7%)
BRAF mutants1G1394TWTdGroup I
1T1787GWTGroup I
Group I2/19 (11%)
KRAS mutants30WTMUTe
Group I7/11 (64%)
C11/8 (13%)
C25/7 (71%)
C35/11 (45%)
C43/11 (27%)
Others9/39 (23%)
Others57WTWT
  • a Exons 11 or 15.

  • b Codons 12, 13, or 61.

  • c Clusters defined in Ref. 8 .

  • d WT, wild-type sequence.

  • e MUT, mutant sequence.