Table 1

Conventional heparin-binding domainsa

MoleculeGroupHBD sequenceMotif
aFGF (17)GFbPLGNYKKPKLLYCSNGXBBXBX
bFGF (22)GFGHFKDPKRLYCKNGGF?(XBBXXXBX)
β-TG (23)GFPDAPRIKKIVQKKLAGXBXBBX
FGFR-1 (23)GF receptorAAPVAHLKKEMKN?(XBBXXBX)
Noggin (9)TGF-β binding proteinAQGKKQRLSKKLRRKLQMXBBXBX, ?(B)xN
IGFBP-3 (23)GF binding proteinGFYKKKQCRPSKGXBBBXXBX
Apo B (23)Human plasma LDLFIIPSPKRPVKLLSG?(XBBXXBX)
Apo B (17)Human plasma LDLALLKKTKNSEEFXBBXBX
Apo E (23)Human plasma LDLSHLRKLRKRLLRDAXBBBXXBX
Apo E (17)Human plasma LDLAWGERLRARMEEMGSRTRDRL?(XBX)xN
TFPI (14)Tissue factor pathway inhibitorGGLIKTKRKRKKQRVKIAY?(B)xN
PVC-21 MuLV (12)Murine leukemia virusPGSHRPRKAKSCXBBXBX
PRV-Be (11)Pseudorabies virusSRRKPPRN…YRRGRFXBBBXXBX, XBBXBX
α4N(V)-NTD (24)Adhesion moleculeRRRKGKGKKKDRGRKGKG(XBBXB)x3, ?(B)xN
α4 Type V collagen (24)CollagenPRRRKGKGKKKDRGRKGKGRKKNKTXXBBXBX, ?(B)xN
Laminin α1 (25)Adhesion moleculeDVRKRLQVQLSIRT?(XBBBX)
Annexin II tetramer, p36 (23)Adhesion moleculeLKIRSEFKKKYGKSLYYXBBBXXBX
Pro-islet amyloid polypeptide (16)Regulatory peptideTPIESHQVEKRKCNTATC?(XBBBX)
Heparin affin regulatory peptide (HARP) (15)Regulatory peptideGKLTKPKQAESKKKKKE?(B)xN
  • a HBDs have been designated by common motifs XBBXBX or XBBBXXBX (17). The ? indicates suggested potential motifs.

  • b GF, growth factor; TGF, transforming growth factor.