Table 1

Clinicopathological characteristics of breast carcinomas from BRCA1 mutation carriers in comparison to control cancers

BRCA1Control
Clinical characteristics
 No. of tumors analyzed2842
 Patients with breast and ovarian carcinoma39
 Patients with bilateral breast carcinomas1222
 Pairs of bilateral breast carcinomas analyzed513
 Mean age at diagnosis (range)40 (28–62)51 (31–73)
Histology
 Invasive ductal carcinoma2835
 Invasive lobular carcinoma02
 Other05
 Grade I03
 Grade II620
 Grade III2219
Immunohistochemistry
 ER +a12% (3/24)57% (21/37)
 PR+17% (4/23)44% (16/36)
 Neu + 0% (0/22)11% (4/35) 
 Cyclin D1 + 0% (0/13)15% (5/34) 
 P53 +41% (9/22)26% (9/34) 
  • a ER, estrogen receptor; PR, progesterone receptor; Neu, HER2-neu; +, positive.