Clinicopathological characteristics of breast carcinomas from BRCA1 mutation carriers in comparison to control cancers
| BRCA1 | Control | |
|---|---|---|
| Clinical characteristics | ||
| No. of tumors analyzed | 28 | 42 |
| Patients with breast and ovarian carcinoma | 3 | 9 |
| Patients with bilateral breast carcinomas | 12 | 22 |
| Pairs of bilateral breast carcinomas analyzed | 5 | 13 |
| Mean age at diagnosis (range) | 40 (28–62) | 51 (31–73) |
| Histology | ||
| Invasive ductal carcinoma | 28 | 35 |
| Invasive lobular carcinoma | 0 | 2 |
| Other | 0 | 5 |
| Grade I | 0 | 3 |
| Grade II | 6 | 20 |
| Grade III | 22 | 19 |
| Immunohistochemistry | ||
| ER +a | 12% (3/24) | 57% (21/37) |
| PR+ | 17% (4/23) | 44% (16/36) |
| Neu + | 0% (0/22) | 11% (4/35) |
| Cyclin D1 + | 0% (0/13) | 15% (5/34) |
| P53 + | 41% (9/22) | 26% (9/34) |
a ER, estrogen receptor; PR, progesterone receptor; Neu, HER2-neu; +, positive.