Table 1

IC50 values (in nm) of two alternative Abl kinase inhibitors against various Abl kinase mutants derived from biochemical (kinase assay) and cell based (MTT-assay) assays

Imatinib mesylatePD180970
Kinase assayMTT assayKinase assayMTT assay
Vector only>10,000710
Wild-type253004525
Q252HND2,800ND130
Y253F1,8003,04048120
E255K>5,0004,40033140
T315I>5,000>10,0003,200840
M351TND930ND45
A380T3402,450435
H396P3404,2004815