Numbers of genes showing significant correlation with sensitivity to nine anticancer drugsa
| All xenografts (85) | NSCLC (11) | Breast cancer (14) | Gastric cancer (13) | |
|---|---|---|---|---|
| 5FU | 240 | 184 | 69 | 72 |
| ACNU | 290 | 151 | 78 | 101 |
| ADR | 283 | 72 | 94 | 93 |
| CPM | 459 | 168 | 103 | 92 |
| DDP | 217 | 166 | 76 | 100 |
| MMC | 321 | 137 | 199 | 102 |
| MTX | 219 | 92 | 75 | 171 |
| VCR | 244 | 200 | 107 | 112 |
| VLB | 210 | 201 | 109 | 60 |
a These genes were identified not only in 85 xenografts but also in xenografts from NSCLC, breast cancer, and gastric cancer in order to explore the genes related to tissue-dependent chemosensitivity. These genes satisfied the following criteria: P < 0.01, and the absolute value of the slope of the regression line was larger than 1.5 between the 100-T/C range (see “Materials and Methods”).