Table 1

Association of elevated Cox-2 immunopositivity (score 2–3) with clinicopathological parameters

Clinicopathological parameterCox-2 staining (positive/total)Cox-2 positive (%)Pa (odds ratio)
Age at diagnosis (yr)
 <50147/41835.2NS;b 0.167
 ≥50442/115838.2(0.88; 0.69–1.12)
Tumor size (cm)
 ≤2 cm288/89432.2<0.0001
 >2 cm276/60145.9(0.56; 0.45–0.70)
Axillary node status
 Negative331/98333.7=0.0001
 Positive231/53043.6(0.66; 0.53–0.82)
Histologic gradec
 I47/18325.7<0.0001
 II181/49236.8
 III148/28452.1
Histologic type
 Ductal461/115539.9=0.0017
 Lobular74/25129.5
 Special48/15630.8
ER
 Negative234/44752.3<0.0001
 Positive330/98833.4(0.46; 0.36–0.58)
PgR
 Negative314/64348.8<0.0001
 Positive249/78631.7(0.49; 0.39–0.61)
Tumor proliferation
 Ki-67 <20%277/84033.0<0.0001
 Ki-67 ≥20%264/48954.0(0.42; 0.33–0.53)
p53 expression
 Negative/Low391/107036.5<0.0001
 High143/24259.1(0.40; 0.30–0.54)
HER-2 oncogene amplification
 Negative425/115736.7<0.0001
 Positive132/26250.4(0.57; 0.43–0.76)
  • a χ2 test.

  • b NS, not significant.

  • c Ductal type only.