Table 2

Five-year DDFS according to Cox-2 expression level

Clinicopathological parameterCox-2 scoren (%)DDFS (95% CI)Pa
Age <50 yr0–1271 (64.8)79 (74–84)NS;b 0.058
2 –3147 (35.2)71 (64–79)
Age ≥50 yr0–1716 (61.8)85 (82–88)<0.0001
2–3442 (38.2)74 (69–78)
Size ≤2 cm0–1606 (67.8)89 (86–91)0.013
2–3288 (32.2)83 (79–88)
Size >2 cm0–1325 (54.1)72 (67–77)NS; 0.052
2–3276 (45.9)64 (58–70)
Node negative0–1652 (66.3)90 (88–92)0.011
2–3331 (33.7)86 (82–90)
Node positive0–1299 (56.4)69 (64–74)0.006
2–3231 (43.6)56 (49–63)
Grade 1c0–1136 (74.3)96 (93–100)0.037
2–347 (25.7)91 (82–100)
Grade 2c0–1311 (63.2)78 (74–83)0.009
2–3181 (36.8)70 (63–77)
Grade 3c0–1136 (47.9)69 (61–77)NS; 0.543
2–3148 (52.1)64 (55–72)
Ductal0–1694 (60.1)81 (78–84)<0.0001
2–3461 (39.9)70 (66–75)
Lobular0–1177 (70.5)87 (82–92)NS; 0.232
2–374 (29.5)81 (71–91)
Special0–1108 (69.2)94 (89–99)NS; 0.396
2–348 (30.8)91 (83–100)
ER positive0–1658 (66.6)86 (84–89)<0.0001
2–3330 (33.4)76 (72–81)
ER negative0–1213 (47.7)70 (64–77)NS; 0.396
2–3234 (52.3)68 (62–74)
PgR positive0–1537 (68.3)88 (86–91)0.002
2–3249 (31.7)80 (74–85)
PgR negative0–1329 (51.2)73 (68–78)NS; 0.071
2–3314 (48.8)67 (62–73)
Ki-67 <20%0–1563 (67.0)87 (84–90)0.001
2–3277 (33.0)77 (72–82)
Ki-67 ≥20%0–1225 (46.0)71 (64–77)NS; 0.097
2–3264 (54.0)67 (61–73)
p53 negative/low0–1679 (63.5)85 (82–88)<0.0001
2–3391 (36.5)74 (70–79)
p53 high0–199 (40.9)64 (54–74)NS; 0.842
2–3143 (59.1)68 (60–76)
HER-2 negative0–1732 (63.3)86 (84–89)<0.0001
2–3425 (36.7)77 (73–81)
HER-2 positive0–1130 (49.6)63 (54–71)NS; 0.729
2–3132 (50.4)59 (50–68)
  • a Log-rank test or log-rank test for a trend.

  • b NS, not significant.

  • c Ductal type only.