Table 1

Anticancer drugs used in analysis

TypeDrug nameTarget/mode of action
Vinca alkaloidsCamptothecinTopo I
IrinotecanTopo I
SN-38Topo I
VincristineTubulin
VinblastineTubulin
VindecineTubulin
TaxanesPaclitaxelTubulin
DocetaxelTubulin
AntibioticsActinomycin DRNA synthesis
BleomycinDNA synthesis
PeplomycinDNA synthesis
MitoxantroneDNA synthesis
Mitomycin CDNA alkylator
AnthracyclinesEpirubicinDNA synthesis/Topo II
DoxorubicinDNA synthesis/Topo II
DaunorubicinDNA synthesis/Topo II
PirarubicinDNA synthesis/Topo II
AclarubicinDNA/RNA synthesis
AntimetabolitesMethotrexateDHFRa
10EdAMDHFR
5-fluorouracilPyrimidine
DoxifluridinePyrimidine
CarmofurPyrimidine
TegafurPyrimidine
CytarabinePyrimidine
GemcitabinePyrimidine
EnocitabinePyrimidine
6-thioguaninePurine
6-mercaptopurinePurine
DNA alkylatorsCisplatinDNA cross-linker
CarboplatinDNA cross-linker
OxaliplatinDNA cross-linker
BusulfanDNA cross-linker
MelphalanDNA cross-linker
ThiotepaDNA cross-linker
DacarbazineDNA synthesis
CarboquoneDNA synthesis
Nitrogen mustardDNA synthesis
Other DNA-damaging agentsEtoposideTopo II
AmsacrineTopo II
GenisteinTopo II
EllipticineTopo II
ICRF154Topo II
NeocarzinostatinDNA synthesis
CladribineDNA synthesis
TomudexDNA synthesis
Hormone analoguesTamoxifenEstrogen receptor
ToremifeneEstrogen receptor
EstramustineEstradiol/nitrogen mustard
InterferonsInterferon-αBiological response modifier
Interferon-βBiological response modifier
Interferon-γBiological response modifier
OthersSTI 571Abl kinase inhibitor
L-asparaginaseProtein synthesis
PSC833P-glycoprotein
  • a DHFR, dihydrofolate reductase; 10EdAM, 10ethyl-lodeaza-aminopterin.