Table 2

The density of methylated CpGs in the p14ARF gene

No. of methylated CpGs0–45–910–1415–1920–2425–28Total
Normal930000093
Dysplasia431112048
Carcinoma770204891
Total21313168232
  • In each sample, more than 10 clones of p14ARF PCR product were examined by bisulfite sequencing. Kruskall-Wallis test: P = 0.0005.