Table 4

Cytotoxicity of ex vivo incubation with 50 ng/ml DT388IL3 against NOD/SL-ICsa

PatientWeek 4Weeks 12–16
ControlDT388IL3ControlDT388IL3
148± 6.8 (5)3.5± 0.89 (5)87± 8.5 (5)68± 7.8 (5)
280± 4.0 (5)3.8± 1.6 (5)17± 12 (5)42± 5.4 (5)
346± 9.9 (5)0.6± 0.16 (5)93± 1.6 (5)32± 17 (5)
40.3± 0.15 (5)1.2± 0.25 (5)14± 7.5 (5)35± 3.0 (5)
570± 8.7 (4)0.1± 0.06 (4)b53± 19 (3)0.03± 0.02 (4)b
60.03± 0.02 (6)0.1± 0.03 (5)14± 12 (5)0.6± 0.18 (3)
72.1± 1.0 (4)0.01± 0.01 (5)b17± 12.5 (3)0± (5)b
  • a Mean ± SE percentage of CD45+ cells in NOD/SCID mouse BM 8–12 weeks after injection of AML cells cultured for 24 h without (control) or with exposure to DT388IL3 (numbers of mice analyzed).

  • b P < 0.05 for comparison between treated and untreated AML cells.