Table 7

Cytotoxicity of DT388IL3 against normal BM RCs

BMWeek 4 RCs/106 cellsaWeek 8 RCs/106 cellsaWeek 12 RCs/106 cellsa
ControlDT388IL3ControlDT388IL3ControlDT388IL3
10.6 (0.2–1.5)b4.7 (1.4–16.1)1.8 (0.7–5.1)4.7 (1.4–16.1)0.7 (0.3–1.8)2.9 (0.9–8.6)
23.9 (0.9–15.7)11 (3–36)4.5 (0.9–21.9)4.7 (1.6–13.8)5.5 (0.17–17.8)7.3 (1.4–38.7)
  • a RC frequency determined as described in “Materials and Methods” and expressed per 106 lin BM cells initiating 24-h cultures ± 50 ng/ml DT388IL3.

  • b 95% confidence interval.