Characterization of solid tumors in trp53+/tm1 mice. Incidence, associated life span, and tumor weight at the time of death are specified for each histologic type of sarcoma for CD44+/+ and CD44−/− genetic background. Life span and tumor weight are indicated as mean ± standard error.
| Tumor | Incidence | Life span | Weight | ||
|---|---|---|---|---|---|
| Osteosarcoma | |||||
| trp53CD44 | 6 (25%) 5 f, 1 ma | 532 ± 30 days | P > 0.05 | 7.7 ± 2.4 grams | P > 0.05 |
| trp53CD44 | 4 (15%) 3 f, 1 m | 467 ± 56 days | 6.1 ± 1.7 grams | ||
| Fibrosarcoma | |||||
| trp53CD44 | 7 (29%) 4 f, 3 m | 410 ± 23 days | P > 0.05 | 21.9 ± 5.0 grams | P > 0.05 |
| trp53CD44 | 7 (27%) 5 f, 2 m | 403 ± 30 days | 12.3 ± 2.9 grams | ||
| Hemangiosarcoma | |||||
| trp53CD44 | 3 (12%) 2 f, 1 m | 304 ± 51 days | 10.7 ± 8.1 grams | ||
| trp53CD44 | 0 (0%) | ||||
| trp53CD44 | 1 (3%) 1 m | 595 days | 2.9 grams | ||
| Histiocytic sarcoma | |||||
| trp53CD44 | 2 (8%) 2 m | 589/590 days | |||
| trp53CD44 | 1 (4%) 1 f | 420 days | |||
| trp53CD44 | 1 (6%) 1 m | 600 days | |||
a f = female; m = male.