Table 1

Characterization of solid tumors in trp53+/tm1 mice. Incidence, associated life span, and tumor weight at the time of death are specified for each histologic type of sarcoma for CD44+/+ and CD44−/− genetic background. Life span and tumor weight are indicated as mean ± standard error.

TumorIncidenceLife spanWeight
Osteosarcoma
 trp53CD446 (25%) 5 f, 1 ma532 ± 30 daysP > 0.057.7 ± 2.4 gramsP > 0.05
 trp53CD444 (15%) 3 f, 1 m467 ± 56 days6.1 ± 1.7 grams
Fibrosarcoma
 trp53CD447 (29%) 4 f, 3 m410 ± 23 daysP > 0.0521.9 ± 5.0 gramsP > 0.05
 trp53CD447 (27%) 5 f, 2 m403 ± 30 days12.3 ± 2.9 grams
Hemangiosarcoma
 trp53CD443 (12%) 2 f, 1 m304 ± 51 days10.7 ± 8.1 grams
 trp53CD440 (0%)
 trp53CD441 (3%) 1 m595 days2.9 grams
Histiocytic sarcoma
 trp53CD442 (8%) 2 m589/590 days
 trp53CD441 (4%) 1 f420 days
 trp53CD441 (6%) 1 m600 days
  • a f = female; m = male.