Table 1

Cross-resistance profiles of doxorubicin-resistant fibroblast cell lines

Shown for each cell line and drug combination: IC50 ± SD (nM) with resistance factors in bold below the IC50s.

DrugMEF3.8an = 3MEF3.8/M32an = 3MEF3.8/T6400an = 3KOT52 n = 4KOT52/D80 n = 2KOT52/D320 n = 588.6 n = 388.6/D200-A n = 288.6/D800-A n = 388.6/D200-B n = 288.6/D800-B n = 3
Mitoxantrone0.81 ± 0.25142 ± 853 ± 61.33 ± 0.13210 ± 70420 ± 602.4 ± 0.3295 ± 30600 ± 90275 ± 20650 ± 150
174 66 158 318 123 250 115 269
Bisantrene12.5 ± 3.0215 ± 22110 ± 109.7 ± 2.5385 ± 641850 ± 40011 ± 1.1540 ± 852500 ± 560450 ± 904400 ± 600
17 8.8 40 191 48 222 40 394
Doxorubicin6.4 ± 1.056 ± 833 ± 93.5 ± 0.5140 ± 321100 ± 3008.3 ± 1.6260 ± 501400 ± 180230 ± 151300 ± 200
8.7 5.2 39 312 31 172 28 156
Daunorubicin7.4 ± 1.514.5 ± 0.512.3 ± 1.24.0 ± 0.334 ± 6330 ± 206.5 ± 0.267 ± 4500 ± 14051 ± 9390 ± 60
2.0 1.7 8.6 82 10 77 7.8 60
Topotecan49 ± 36400 ± 200016000 ± 5300166 ± 6917500 ± 70023000 ± 500098 ± 1111000 ± 20004300 ± 17506700 ± 6003200 ± 1200
132 329 105 137 109 44 69 32
Vincristine0.38 ± 0.030.64 ± 0.070.63 ± 0.230.82 ± 0.090.72 ± 0.180.98 ± 0.224.1 ± 0.46.1 ± 0.44.1 ± 0.76.2 ± 0.47.3 ± 0.7
1.7 1.6 0.87 1.2 1.5 1.0 1.5 1.8
Paclitaxel4.5 ± 0.38.4 ± 1.99.1 ± 3.02.2 ± 0.42.7 ± 0.13.4 ± 1.45.8 ± 0.48.0 ± 0.15.9 ± 1.53.8 ± 0.64.1 ± 0.8
1.9 2.0 1.2 1.7 1.4 1.0 0.7 0.7
  • a These data are taken for comparison from Ref. 3 .