Table 4

Reversal of cross-resistance in doxorubicin-selected cell lines by the BCRP/Bcrp1 inhibitor Ko143

Values shown are the resistance factors in the absence (as per Table 1 <$REFLINK> ) or presence of 200 nM Ko143. Some assays in the presence of Ko143 were performed on two occasions; in these cases both results are shown.

DrugKo143Cell line
KOT52KOT52/D32088.688.6/D800-A88.6/D800-B
Mitoxantrone13181250269
+0.532.10.401.63.3
Bisantrene11911222394
+0.482.3, 2.40.96, 1.12.1, 2.34.8, 7.6
Doxorubicin13121172156
+0.696.6, 7.10.82, 1.352.9, 3.63.7, 5.9
Topotecan113714432
+0.301.00.680.600.76