Table 2

Genotype frequencies of sequence variants of hOGG1 in cases and controls (Caucasians only)

SNPsGenotypeNo. of subjects (%)Ps (vs. control)a
ControlsSporadicHPCSporadicHPC
3402G/A AA 79 (43)73 (40)
AG 83 (45)81 (44)
GG 23 (12)29 (16)N.S.b
3574G/A AA 104 (60)128 (67)
AG 58 (34)54 (28)
GG 11 (6)10 (5)N.S.
6170G/C CC 101 (58)130 (63)
CG 60 (34)69 (33)
GG 13 (7)8 (4)N.S.
6803C/G (Ser326Cys) CC 96 (55)122 (61)60 (61)
CG 63 (36)71 (36)35 (35)
GG 15 (9)6 (3)4 (4)0.0550.34
7143A/G AA 130 (71)153 (68)83 (64)
AG 52 (28)59 (26)41 (32)
GG 2 (1)12 (5)6 (5)0.0590.11
9110A/G GG 110 (60)138 (66)
GA 62 (34)66 (31)
AA 12 (7)6 (3)N.S.
10629C/G CC 53 (30)54 (28)
CG 73 (41)84 (44)
GG 53 (30)51 (27)N.S.
10660A/T TT 111 (61)140 (65)
TA 59 (32)69 (32)
AA 12 (7)8 (4)N.S.
11657A/G AA 139 (74)158 (70)88 (67)
AG 47 (25)56 (25)38 (29)
GG 1 (1)11 (5)6 (5)0.0280.03
11826A/T AA 110 (60)138 (66)
AT 60 (33)64 (31)
TT 12 (7)7 (3)N.S.
  • a FET.

  • b N.S., not significant.