Table 1

Summary of copy number ratios of 18 chromosome 17q12-q21 transcripts in eight xenografts and three cell lines of gastric cancer by CGH microarraya

GeneUnigene IdAccessionAlignmentbLocusbSamples
X11X27X57X71X75X79X83X95CRL- 5822CRL- 5973CRL- 5974
MRPL45 Mitochondrial ribosomal protein L45Hs. 19347AI27778538274220/5192278717q12/17q21.31.4 1.5 1.1 1 2.4 1.3 1.6 1.6 2 1.41.2
MKP-1 like protein tyrosine phosphatase (MKP-L)Hs. 91448AA1296773874727917q12 1.9 1.6 0.81.41.11.11.2 2.8 1.41.4 1.7
LIM homeobox protein 1 (LHX1)Hs. 157449AI3755653930791617q1211.3 2.1 1.1 2.8 1.21 2.8 1.4 2.5 2.1
Phosphatidylinositol-4-phosphate 5-kinase, type II, β (PIP5K2B)Hs. 6335H802634061773117q1210.9 1.6 1.7 1.31.30.9 1.7 1.4 2.8 0.8
ESTHs. 91668H160944191120517q21.11.20.81.211.4 3.8 4.7 0.9 3.1 1.20.8
EST (FLJ20940 hypothetical protein)Hs. 286192AA5525094186858417q21.11.41.1 1.7 1.21.4 5.8 7.3 1.6 1.5 1.41.1
H. sapiens MLN64 mRNAHs. 77628AA5046154187724617q21.11.11.11.21.21.2 5.5 4.2 1.1 3.1 1.41.1
V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)Hs. 323910AA4469284194022917q21.111111.1 2.6 2.1 1 1.7 1.11
ESTHs. 46645AA2839054197268017q21.11.31.111.30.9 5.1 10.4 1.3 2 0.81.3
ESTHs. 318893AA4552914197841517q21.11.10.91.110.9 7.8 2.5 0.8 3.2 1.40.9
Growth factor receptor-bound protein 7 (GRB7)Hs. 86859H537034198921017q21.11.4111.11 5.7 8.9 0.9 2.7 1.41
H. sapiens MLN51 mRNAHs. 83422R529744233185717q21.1 1.6 1.21.1 1.6 0.9 1.9 1.9 1.5 1.4 2.1 1.1
Topoisomerase (DNA) II α (170kD) (TOP2A)Hs. 156346AA0266824252125417q21.21.31.11.2 1.6 1 1.7 1.6 1.4 1.6 1.41.1
ESTHs. 13268AA5143614405692217q21.21.21.11 1.9 1.3 2.3 1.2 1.8 1.5 1.8 1.5
ATP citrate lyase (ACLY)Hs. 174140R559744407531117q21.21.211 1.6 1 1.6 1.1 1.6 1.4 1.6 2.3
ESTHs. 38039H622714457493717q21.2 5.7 2.9 2.3 6.7 3.1 1 1.7 2.5 3 4.3 2.7
Ribosomal protein L27 (RPL27)Hs. 111611AA1908814530113617q21.2 4.6 2.5 2.2 6.1 1.7 0.9 2 2 2.1 1.4 2.9
EST (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 8, DDX8)Hs. 171872AI5406634605495717q21.31.4 1.7 0.51.40.9 2.9 1.6 1.2 1.9 3.7 1.1
  • a Copy number ratios above the 1.5 threshold are shown in bold.

  • b Alignment (bp position) and locus are shown according to Santa Cruz August freeze 2001 assembly.