Table 2

Percentage ring opening of [11C]temozolomide for the full duration of the scan

This was calculated from the ratio of total [11C]tracer: [11C]temozolomide after injection of [4-11C-carbonyl] temozolomide. Ring opening was greater in tissues compared with plasma (P < 0.05). However, there was no tumor-specific ring opening, as no differences in percentage ring opening were observed between tumor and normal tissues.

Patient no.PlasmaTumorGrey matterWhite matter
118.7326.8928.3226.80
227.7933.3326.1326.56
321.5420.5827.7828.75
421.0430.6638.1838.36
518.9921.7829.3628.24
617.2527.4228.4432.05
Mean20.8926.7829.7030.13
(SE)(1.5)(2.0)(1.8)(1.8)