Table 3

Risk of breast cancer associated with the combination of the number of putative high-risk genotypes of NHEJ genes and a reproductive risk factor (history of full-term pregnancy)

Reproductive risk factoraOR (95% CI)a
No. of high-risk genotypes of NHEJ genes
≤1>1
Having a history of full-term pregnancy
 Yes1.00 (Ref.)b2.42 (1.61–3.65)
 No2.75 (0.92–8.26)5.29 (2.67–10.49)
  • a The aOR of breast cancer development associated with the number of putative high-risk genotypes and pregnancy was estimated in a multivariate logistic regression model containing age, family history of breast cancer, BMI, and a group of dummy variables to represent the four different combinations of gene (number of putative high-risk genotype) and reproductive risk factor status.

  • b Ref., reference group.