Table 1

Number of ACF and MDF/colon and their multiplicity (ACs/ACF and crypts/MDF) in AOM-treated rats fed a control diet or a diet containing synbiotics

ACF were evaluated in methylene blue-stained colons, whereas MDF were evaluated in the same methylene blue-stained colons restained with HID-AB. Rats were sacrificed 7 and 15 weeks after AOM.

Weeks after AOMACF/colonAC/ACFMDF/colonCrypts/MDF
ControlSynbioticControlSynbioticControlSynbioticControlSynbiotic
7271 ± 15250 ± 212.1 ± 0.12.5 ± 0.1c4.2 ± 0.75.7 ± 0.63.9 ± 0.83.9 ± 0.5
15298 ± 25322 ± 22a2.6 ± 0.1b3.1 ± 0.1b,c8.2 ± 0.9b3.8 ± 0.9c12.2 ± 2.0b6.4 ± 1.0a,c
  • a Significantly different from its respective column value at 7 weeks (P < 0.05; means ± SE, n = 7).

  • b Significantly different from its respective column value at 7 weeks (P < 0.01; means ± SE, n = 7).

  • c Significantly different from the value in rats fed the control diet (P < 0.01).