Table 2

Grade of histological dysplasia in mucinous lesions identified as ACF in HID-AB-stained colon and MDF harvested 7 and 15 weeks after the first AOM injection

Values are means ± SD.

Dysplasia parameters7 weeks15 weeks
ACF (n = 28)MDF (n = 18)ACF (n = 28)MDF (n = 20)
Increase in nuclear:cytoplasmatic ratio1 ± 00.89 ± 0.321 ± 00.95 ± 0.22
Nuclear stratification0.53 ± 0.500.61 ± 0.500.57 ± 0.500.8 ± 0.41
Loss of nuclear polarity00.05 ± 0.2300
Irregularity in the nuclear outline0.04 ± 0.180.06 ± 0.2300.2 ± 0.41a
Nuclear crowding0.86 ± 0.360.78 ± 0.420.75 ± 0.440.95 ± 0.22
Number of mitoses0.11 ± 0.310.17 ± 0.380.07 ± 0.260.25 ± 0.44
Mucin depletion0.39 ± 0.491.5 ± 0.78a0.71 ± 0.591.1 ± 0.44a
Structural abnormality of the crypts0.46 ± 0.500.72 ± 0.460.5 ± 0.510.7 ± 0.47
Total score3.39 ± 1.344.78 ± 2.23a3.61 ± 1.614.95 ± 1.60a
  • a Significantly different when compared with ACF harvested at the same time (P < 0.01 by Mann-Whitney U test).